Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20726
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dc.contributor.authorTheuerle, James D-
dc.contributor.authorFarouque, Omar-
dc.contributor.authorVasanthakumar, Sheran-
dc.contributor.authorPatel, Sheila K-
dc.contributor.authorBurrell, Louise Men
dc.contributor.authorClark, David J-
dc.contributor.authorAl-Fiadh, Ali H-
dc.date2019-04-02-
dc.date.accessioned2019-04-30T23:55:28Z-
dc.date.available2019-04-30T23:55:28Z-
dc.date.issued2019-
dc.identifier.citationInternational journal of cardiology 2019; 291: 168-172en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20726-
dc.description.abstractEndothelin-1 (ET-1) is a vasoconstrictor associated with cardiovascular disease, whereas adrenomedullin (ADM) is a vasorelaxant with cardioprotective properties. We sought to determine the relationship between plasma ET-1 and ADM with coronary circulatory function and long-term major adverse cardiovascular events (MACE). Thirty-two patients undergoing coronary angiography for chest pain were recruited. Baseline plasma ET-1 and ADM levels were measured. The index of microcirculatory resistance (IMR), coronary flow mediated dilatation (cFMD) and coronary flow reserve (CFR) were measured in a non-obstructed coronary artery. Patients were assessed for MACE over a median period of 8.8 years. Plasma ET-1 levels correlated with IMR (r = 0.57; p < 0.01) and ADM levels correlated with CFR (r = 0.50; p = 0.04) and cFMD (r = 0.62; p = 0.01). After adjustment for age, gender and cardiovascular risk factors, the association between ADM and cFMD (β = 0.79; p < 0.01) and between ET-1 and IMR (β = 5.7; p = 0.01) remained significant. IMR was higher, although not statistically significant, in patients with long-term MACE (17.9 ± 5.3 vs. 13.1 ± 6.0 units; p = 0.14). In patients free of MACE, cFMD (9.3 ± 7.6 vs. 2.8 ± 5.0%; p = 0.01) and plasma ADM levels (7.6 ± 5.3 vs. 4.0 ± 1.9 pmol/L; p = 0.07) were higher. Plasma ET-1 and ADM were associated with measures of coronary microvascular and coronary conduit vessel function, respectively. Increased cFMD and elevated plasma ADM were associated with a cardioprotective effect.en
dc.language.isoeng-
dc.subjectAdrenomedullinen
dc.subjectCoronary flow mediated dilatationen
dc.subjectCoronary microcirculationen
dc.subjectEndothelinen
dc.titlePlasma endothelin-1 and adrenomedullin are associated with coronary artery function and cardiovascular outcomes in humans.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational journal of cardiologyen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Cardiology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.ijcard.2019.04.008en
dc.type.contentTexten
dc.identifier.orcid0000-0002-0626-1899en
dc.identifier.orcid0000-0003-1863-7539en
dc.identifier.pubmedid30987836-
dc.type.austinJournal Article-
local.name.researcherBurrell, Louise M
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptUniversity of Melbourne Clinical School-
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