Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20684
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dc.contributor.authorAlif, Sheikh M-
dc.contributor.authorDharmage, Shyamali-
dc.contributor.authorBenke, Geza-
dc.contributor.authorDennekamp, Martine-
dc.contributor.authorBurgess, John-
dc.contributor.authorPerret, Jennifer L-
dc.contributor.authorLodge, Caroline-
dc.contributor.authorMorrison, Stephen-
dc.contributor.authorJohns, David Peter-
dc.contributor.authorGiles, Graham-
dc.contributor.authorGurrin, Lyle-
dc.contributor.authorThomas, Paul S-
dc.contributor.authorHopper, John Llewelyn-
dc.contributor.authorWood-Baker, Richard-
dc.contributor.authorThompson, Bruce-
dc.contributor.authorFeather, Iain-
dc.contributor.authorVermeulen, Roel-
dc.contributor.authorKromhout, Hans-
dc.contributor.authorJarvis, Debbie-
dc.contributor.authorGarcia Aymerich, Judith-
dc.contributor.authorWalters, E Haydn-
dc.contributor.authorAbramson, Michael J-
dc.contributor.authorMatheson, Melanie Claire-
dc.date2019-04-26-
dc.date.accessioned2019-04-30T23:55:25Z-
dc.date.available2019-04-30T23:55:25Z-
dc.date.issued2019-07-
dc.identifier.citationThorax 2019; 74(7): 650-686-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20684-
dc.description.abstractWhile cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements. We aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study. Lung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status. Compared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV1 (aromatic solvents 15.5 mL/year (95% CI -24.8 to 6.3); metals 11.3 mL/year (95% CI -21.9 to - 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI -28.8 to - 0.7; metals 17.5 mL/year (95% CI -34.3 to - 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function. Exposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.-
dc.language.isoeng-
dc.subjectFEV1-
dc.subjectchronic obstructive pulmonary disease-
dc.subjectjob exposure matrix-
dc.subjectlung function-
dc.subjectoccupational exposure-
dc.subjectsolvents-
dc.titleOccupational exposure to solvents and lung function decline: A population based study.-
dc.typeJournal Article-
dc.identifier.journaltitleThorax-
dc.identifier.affiliationEnvironmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands-
dc.identifier.affiliationNational Heart and Lung Institute, Imperial College, London, United Kingdom of Great Britain and Northern Ireland-
dc.identifier.affiliationISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain-
dc.identifier.affiliationEnvironmental Public Health, Environment Protection Authority Victoria, Melbourne, Victoria, Australiaen
dc.identifier.affiliationAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSchool of Medicine, University of Tasmania, Hobart, Tasmania, Australiaen
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMedicine, Gold Coast University Hospital, Southport, Queensland, Australiaen
dc.identifier.affiliationHealth Sciences, Swinburne University of Technology, Melbourne, Victoria, Australiaen
dc.identifier.affiliationFaculty of Medicine, University of new South Wales, Sydney, New South Wales, Australiaen
dc.identifier.affiliationDepartment of Medicine, University of Queensland, Brisbane, Queensland, Australiaen
dc.identifier.doi10.1136/thoraxjnl-2018-212267-
dc.identifier.orcid0000-0002-0783-8848-
dc.identifier.orcid0000-0001-7034-0615-
dc.identifier.orcid0000-0002-1753-3896-
dc.identifier.orcid0000-0002-7097-4586-
dc.identifier.pubmedid31028237-
dc.type.austinJournal Article-
local.name.researcherPerret, Jennifer L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInstitute for Breathing and Sleep-
Appears in Collections:Journal articles
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