Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20639
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dc.contributor.authorMerino, Delphine-
dc.contributor.authorWeber, T S-
dc.contributor.authorSerrano, A-
dc.contributor.authorVaillant, F-
dc.contributor.authorLiu, K-
dc.contributor.authorPal, B-
dc.contributor.authorDi Stefano, L-
dc.contributor.authorSchreuder, J-
dc.contributor.authorLin, D-
dc.contributor.authorChen, Y-
dc.contributor.authorAsselin-Labat, M L-
dc.contributor.authorSchumacher, T N-
dc.contributor.authorCameron, D-
dc.contributor.authorSmyth, G K-
dc.contributor.authorPapenfuss, A T-
dc.contributor.authorLindeman, G J-
dc.contributor.authorVisvader, J E-
dc.contributor.authorNaik, S H-
dc.date2019-02-15-
dc.date.accessioned2019-04-15T05:39:51Z-
dc.date.available2019-04-15T05:39:51Z-
dc.date.issued2019-02-15-
dc.identifier.citationNature Communications 2019; 10(1): 766-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20639-
dc.description.abstractPrimary triple negative breast cancers (TNBC) are prone to dissemination but sub-clonal relationships between tumors and resulting metastases are poorly understood. Here we use cellular barcoding of two treatment-naïve TNBC patient-derived xenografts (PDXs) to track the spatio-temporal fate of thousands of barcoded clones in primary tumors, and their metastases. Tumor resection had a major impact on reducing clonal diversity in secondary sites, indicating that most disseminated tumor cells lacked the capacity to 'seed', hence originated from 'shedders' that did not persist. The few clones that continued to grow after resection i.e. 'seeders', did not correlate in frequency with their parental clones in primary tumors. Cisplatin treatment of one BRCA1-mutated PDX model to non-palpable levels had a surprisingly minor impact on clonal diversity in the relapsed tumor yet purged 50% of distal clones. Therefore, clonal features of shedding, seeding and drug resistance are important factors to consider for the design of therapeutic strategies.-
dc.language.isoeng-
dc.titleBarcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer.-
dc.typeJournal Article-
dc.identifier.journaltitleNature Communications-
dc.identifier.affiliationACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia-
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDivision of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlandsen
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Bundoora, VIC, 3086, Australiaen
dc.identifier.affiliationDepartment of Medical Oncology, The Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australiaen
dc.identifier.affiliationDepartment of Medicine, The University of Melbourne, Melbourne, VIC, 3010, Australiaen
dc.identifier.affiliationParkville Familial Cancer Centre, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, VIC, 3050, Australiaen
dc.identifier.affiliationDepartment of Medical Biology, The University of Melbourne, Melbourne, VIC, 3010, Australiaen
dc.identifier.affiliationBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australiaen
dc.identifier.affiliationSchool of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, 3010, Australiaen
dc.identifier.affiliationPeter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australiaen
dc.identifier.affiliationSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, 3010, Australiaen
dc.identifier.affiliationMolecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australiaen
dc.identifier.affiliationImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australiaen
dc.identifier.affiliationDepartment of Medical Biology, The University of Melbourne, Melbourne, VIC, 3010, Australia-
dc.identifier.doi10.1038/s41467-019-08595-2-
dc.identifier.orcid0000-0002-8075-6275-
dc.identifier.orcid0000-0003-3836-3299-
dc.identifier.orcid0000-0003-3229-3760-
dc.identifier.orcid0000-0001-6187-819X-
dc.identifier.orcid0000-0002-3684-4331-
dc.identifier.orcid0000-0001-8366-9882-
dc.identifier.orcid0000-0002-7579-0006-
dc.identifier.orcid0000-0002-7872-6931-
dc.identifier.orcid0000-0003-4911-5653-
dc.identifier.orcid0000-0001-7082-6076-
dc.identifier.orcid0000-0003-0517-8804-
dc.identifier.orcid0000-0002-0951-7116-
dc.identifier.orcid0000-0001-9221-2892-
dc.identifier.orcid0000-0002-1102-8506-
dc.identifier.orcid0000-0001-9386-2416-
dc.identifier.orcid0000-0001-9173-6977-
dc.identifier.orcid0000-0003-0299-3301-
dc.identifier.pubmedid30770823-
dc.type.austinJournal Article-
dc.type.austinResearch Support, Non-U.S. Gov't-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
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