Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20564
Full metadata record
DC FieldValueLanguage
dc.contributor.authorArulananda, Surein-
dc.contributor.authorLynam, James-
dc.contributor.authorSem Liew, Mun-
dc.contributor.authorWada, Morikatsu-
dc.contributor.authorCher, Lawrence-
dc.contributor.authorGan, Hui K-
dc.date.accessioned2019-04-02T01:08:25Z-
dc.date.available2019-04-02T01:08:25Z-
dc.date.issued2018-10-
dc.identifier.citationInternal Medicine Journal 2018; 48(10): 1206-1214-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/20564-
dc.description.abstractThis study was conducted retrospectively to evaluate rates of thrombocytopenia and their clinical impact during chemo-radiotherapy for glioblastomas and to elucidate associated clinical factors. A total of 64 patients who received temozolomide chemotherapy at our institution was included; 35 patients received full-dose chemo-radiotherapy as per the STUPP protocol (Group A), and 9 patients received abbreviated radiotherapy with concurrent chemotherapy (Group B). Twenty patients received temozolomide alone with an intended 12 cycles of therapy for first relapse at least 6 months after completion of adjuvant chemotherapy (Group C). In Group A, 27 of 35 (77%) patients completed the chemo-radiotherapy phase; 14% had grade 3-4 thrombocytopenia leading to discontinuation. Of 27 patients, 16 (59%) completed adjuvant chemotherapy. There were no grade 3-4 thrombocytopenias, but 4% discontinued due to grade 2 thrombocytopenias. In Group B, four of nine (45%) patients completed the chemo-radiotherapy phase; 11% had grade 3-4 thrombocytopenias and discontinued treatment. Three of four (75%) patients completed adjuvant chemotherapy. Of these, 75% had grade 3-4 thrombocytopenias, but none discontinued. Finally, in Group C, 8 of 20 (40%) patients completed, with 10% discontinuing due to thrombocytopenias and the rest due to disease progression. In exploratory analyses, being female increased the risk of myelosuppresion, and there was a trend noticed in patients having a higher body surface area. Our toxicity data were within range of the literature. We identified the group of patients that have increased thrombocytopenia risk. Larger pooled retrospective series and prospective studies are required.-
dc.language.isoeng-
dc.subjectglioblastoma-
dc.subjectmyelosuppression-
dc.subjectradiotherapy-
dc.subjecttemozolomide-
dc.subjectthrombocytopenia-
dc.titleClinical correlates of severe thrombocytopenia from temozolomide in glioblastoma patients.-
dc.typeJournal Article-
dc.identifier.journaltitleInternal Medicine Journal-
dc.identifier.affiliationVictorian Oncology Care, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medical Oncology, Calvary Mater Newcastle, Newcastle, New South Wales, Australiaen
dc.identifier.affiliationDepartment of Medical Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Cancer Medicine, Latrobe University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationFaculty of Medicine, Dentistry and Health Science, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1111/imj.14000-
dc.identifier.orcid0000-0002-5636-6381-
dc.identifier.pubmedid29923272-
dc.type.austinJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

6
checked on Feb 5, 2023

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.