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dc.contributor.authorBuhre, Wolfgang-
dc.contributor.authorDisma, Nicola-
dc.contributor.authorHendrickx, Jan-
dc.contributor.authorDeHert, Stefan-
dc.contributor.authorHollmann, Markus W-
dc.contributor.authorHuhn, Ragnar-
dc.contributor.authorJakobsson, Jan-
dc.contributor.authorNagele, Peter-
dc.contributor.authorPeyton, Philip J-
dc.contributor.authorVutskits, Laszlo-
dc.identifier.citationBritish journal of anaesthesia 2019; 122(5): 587-604-
dc.description.abstractNitrous oxide (N2O) is one of the oldest drugs still in use in medicine. Despite its superior pharmacokinetic properties, controversy remains over its continued use in clinical practice, reflecting in part significant improvements in the pharmacology of other anaesthetic agents and developing awareness of its shortcomings. This narrative review describes current knowledge regarding the clinical use of N2O based on a systematic and critical analysis of the available scientific literature. The pharmacological properties of N2O are reviewed in detail along with current evidence for the indications and contraindications of this drug in specific settings, both in perioperative care and in procedural sedation. Novel potential applications for N2O for the prevention or treatment of chronic pain and depression are also discussed. In view of the available evidence, we recommend that the supply of N2O in hospitals be maintained while encouraging its economic delivery using modern low flow delivery systems. Future research into its potential novel applications in prevention or treatment of chronic conditions should be pursued to better identify its role place in the developing era of precision medicine.-
dc.subjectdental pain-
dc.subjectlabour analgesia-
dc.subjectmajor depression-
dc.subjectnitrous oxide-
dc.titleEuropean Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice.-
dc.typeJournal Article-
dc.identifier.journaltitleBritish journal of anaesthesia-
dc.identifier.affiliationDepartment of Anesthesiology and Pain Medicine, Maastricht University Medical Center, University of Maastricht, Maastricht, the Netherlands-
dc.identifier.affiliationDepartment of Anesthesia, Istituto Giannina Gaslini, Genoa, Italy-
dc.identifier.affiliationDepartment of Anesthesiology, Amsterdam University Medical Center (AUMC), AMC, University of Amsterdam, Amsterdam, the Netherlandsen
dc.identifier.affiliationAnaesthesia Perioperative and Pain Medicine Unit, Melbourne Medical School, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Anesthesiology, University Hospital Düsseldorf, Düsseldorf, Germanyen
dc.identifier.affiliationDepartment of Anesthesiology, Onze-Lieve-Vrouwziekenhuis Hospital Aalst, Aalst, Belgium-
dc.identifier.affiliationDepartment of Anesthesiology and Perioperative Medicine, University Hospital Ghent, Ghent, Belgium-
dc.identifier.affiliationDepartment of Anesthesiology and Intensive Care, Institution for Clinical Science, Karolinska Institute, Danderyds University Hospital, Danderyd, Sweden-
dc.identifier.affiliationDepartment of Anesthesia and Critical Care, University of Chicago Medicine, Chicago, IL, USA-
dc.identifier.affiliationDepartment of Anesthesiology, Pharmacology and Intensive Care, University Hospitals Geneva, Genève, Switzerland-
dc.identifier.affiliationDepartment of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia-
dc.type.austinJournal Article-
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