Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20428
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dc.contributor.authorFujii, Tomoko-
dc.contributor.authorUdy, Andrew-
dc.contributor.authorLicari, Elisa-
dc.contributor.authorRomero, Lorena-
dc.contributor.authorBellomo, Rinaldo-
dc.date2019-06-
dc.date.accessioned2019-03-14T22:35:08Z-
dc.date.available2019-03-14T22:35:08Z-
dc.date.issued2019-02-26-
dc.identifier.citationJournal of Critical Care 2019; 51: 184-191-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20428-
dc.description.abstractWe aimed to assess the biochemical and physiological effects, clinical efficacy, and safety, of intravenous NaHCO3 therapy in critically ill patients with acute metabolic acidosis. We conducted a scoping review concerning the biochemical and physiological effects of NaHCO3 (PART A), and a systematic review regarding clinical efficacy (PART B). We searched MEDLINE in Part A and MEDLINE, EMBASE, Cochrane, the National Institute of Health Clinical Trials Register, and the WHOICTRP for randomised controlled trials in Part B. Twelve studies in Part A and two trials in Part B fulfilled the eligibility criteria. Intravenous NaHCO3 increased blood pH, base excess, serum bicarbonate, sodium, and PaCO2 during and after administration and decreased anion gap and potassium value. For clinical efficacy, only one study contributed to the effect estimate. The risk ratio (RR) for all-cause mortality was 0.83 (95% confidence interval, 0.68 to 1.02), and the risk of hypocalcaemia was increased in the bicarbonate group (RR 1.65, 95% confidence interval 1.09 to 2.50). There were inadequate data on hemodynamic indices. Given the lack of data on the effects of intravenous NaHCO3 therapy to support its clinical use and the frequency of bicarbonate therapy, a program of investigation appears justified.-
dc.language.isoeng-
dc.subjectIntensive care-
dc.subjectMetabolic acidosis-
dc.subjectSodium bicarbonate-
dc.subjectSystematic review-
dc.titleSodium bicarbonate therapy for critically ill patients with metabolic acidosis: A scoping and a systematic review.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of Critical Care-
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, The Alfred, Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe Ian Potter Library, The Alfred, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Japan Society for the Promotion of Science, Tokyo, Japanen
dc.identifier.affiliationSchool of Medicine, The University of Melbourne, Parkville, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.jcrc.2019.02.027-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.pubmedid30852347-
dc.type.austinJournal Article-
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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