Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20326
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dc.contributor.authorSinclair, Marie-
dc.contributor.authorHoermann, Rudolf-
dc.contributor.authorPeterson, Adam-
dc.contributor.authorTestro, Adam G-
dc.contributor.authorAngus, Peter W-
dc.contributor.authorHey, Penelope-
dc.contributor.authorChapman, Brooke-
dc.contributor.authorGow, Paul J-
dc.date2019-02-12-
dc.date.accessioned2019-03-04T22:04:17Z-
dc.date.available2019-03-04T22:04:17Z-
dc.date.issued2019-06-
dc.identifier.citationLiver International 2019; 39(6): 1089-1097en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20326-
dc.description.abstractReduced muscle area on CT scan is an independent predictor of mortality in cirrhosis. We examine for the first time the relationship between dual energy x-ray absorptiometry (DEXA) lean mass parameters on outcomes in cirrhotic men awaiting liver transplantation. We retrospectively reviewed DEXA scans performed during transplant assessment between 2001 and 2016. Baseline data including the presence of ascites and MELD score were recorded. DEXA lean mass measures were adjusted for height. The primary outcome was 12-month wait-list mortality. Four hundred twenty men with median age 55.4 years [interquartile range 49.2; 59.4] and MELD 16 [12; 20] were studied. Median follow-up was 58.5 [28.8; 109] months. 12-month wait-list mortality was 12.4%. Appendicular lean mass was inversely associated with mortality (HR 0.78 [0.62; 0.98], P = 0.03). Lean mass of arms (HR 0.37 [0.16; 0.83], P  = 0.02) rather than legs (HR 0.77 [0.58; 1.03], P  = 0.08) was responsible for this association. Upper limb lean mass showed a significant interaction with MELD score in predicting wait-list mortality, particularly within 4 months. Total lean mass was not associated with mortality but increased in conjunction with increasing ascites (OR for ascites 1.20 [1.15; 1.25], P < 0.001 for each unit increase in MELD). Upper limb lean mass by DEXA is strongly associated with mortality in men awaiting liver transplantation. The superiority of upper limb lean mass probably relates to confounding of lower limb measures by fluid retention. This DEXA parameter represents a novel and reproducible measure of sarcopenia in cirrhosis.en_US
dc.language.isoeng-
dc.subjectDEXAen_US
dc.subjectcirrhosisen_US
dc.subjectmortalityen_US
dc.subjectsarcopeniaen_US
dc.titleUse of Dual X-ray Absorptiometry in men with advanced cirrhosis to predict sarcopenia-associated mortality risk.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleLiver international : official journal of the International Association for the Study of the Liveren_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.doi10.1111/liv.14071en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-0657-3048en_US
dc.identifier.orcid0000-0002-5219-0382en_US
dc.identifier.orcid0000-0002-7251-8314en_US
dc.identifier.pubmedid30746903-
dc.type.austinJournal Article-
local.name.researcherAngus, Peter W
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptNutrition and Dietetics-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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