Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20285
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dc.contributor.authorAllebone, James-
dc.contributor.authorKanaan, Richard A A-
dc.contributor.authorMaller, Jerome-
dc.contributor.authorO'Brien, Terry-
dc.contributor.authorMullen, Saul A-
dc.contributor.authorCook, Mark-
dc.contributor.authorAdams, Sophia J-
dc.contributor.authorVogrin, Simon-
dc.contributor.authorVaughan, David N-
dc.contributor.authorConnelly, Alan-
dc.contributor.authorKwan, Patrick-
dc.contributor.authorBerkovic, Samuel F-
dc.contributor.authorD'Souza, Wendyl J-
dc.contributor.authorJackson, Graeme D-
dc.contributor.authorVelakoulis, Dennis-
dc.contributor.authorWilson, Sarah J-
dc.date2019-02-22-
dc.date.accessioned2019-03-04T22:04:13Z-
dc.date.available2019-03-04T22:04:13Z-
dc.date.issued2019-06-
dc.identifier.citationJournal of neurology, neurosurgery, and psychiatry 2019; 90(6): 688-694en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20285-
dc.description.abstractPsychosis of epilepsy (POE) occurs more frequently in temporal lobe epilepsy, raising the question as to whether abnormalities of the hippocampus are aetiologically important. Despite decades of investigation, it is unclear whether hippocampal volume is reduced in POE, perhaps due to small sample sizes and methodological limitations of past research. In this study, we examined the volume of the total hippocampus, and the hippocampal head, body and tail, in a large cohort of patients with POE and patients with epilepsy without psychosis (EC). One hundred adults participated: 50 with POE and 50 EC. Total and subregional hippocampal volumes were manually traced and compared between (1) POE and EC; (2) POE with temporal lobe epilepsy, extratemporal lobe epilepsy and generalised epilepsy; and (3) patients with POE with postictal psychosis (PIP) and interictal psychosis (IP). Compared with EC the POE group had smaller total left hippocampus volume (13.5% decrease, p<0.001), and smaller left hippocampal body (13.3% decrease, p=0.002), and left (41.5% decrease, p<0.001) and right (36.4% decrease, p<0.001) hippocampal tail volumes. Hippocampal head volumes did not differ between groups. Posterior hippocampal volumes are bilaterally reduced in POE. Volume loss was observed on a posteroanterior gradient, with severe decreases in the tail and moderate volume decreases in the body, with no difference in the hippocampal head. Posterior hippocampal atrophy is evident to a similar degree in PIP and IP. Our findings converge with those reported for the paradigmatic psychotic disorder, schizophrenia, and suggest that posterior hippocampal atrophy may serve as a biomarker of the risk for psychosis, including in patients with epilepsy.en_US
dc.language.isoeng-
dc.subjectepilepsyen_US
dc.subjecthippocampusen_US
dc.subjectinterictal psychosisen_US
dc.subjectpostictal psychosisen_US
dc.subjectpsychosisen_US
dc.titleBilateral volume reduction in posterior hippocampus in psychosis of epilepsy.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of neurology, neurosurgery, and psychiatryen_US
dc.identifier.affiliationDepartment of Psychiatry, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Neuroscience, Alfred Hospital, Monash University, Melbourne, Australiaen_US
dc.identifier.affiliationSt Vincent's Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationGraeme Clark Institute, University of Melbourne, Melbourne, Australiaen_US
dc.identifier.affiliationANU College of Health and Medicine, Australian National University, Canberra, Victoria, Australiaen_US
dc.identifier.affiliationMonash Alfred Psychiatry Research Centre, The Alfred and Monash University, Melbourne, Australiaen_US
dc.identifier.affiliationMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationComprehensive Epilepsy Programen_US
dc.identifier.affiliationNeuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMelbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, St Vincent's Hospital, The University of Melbourne, Australiaen_US
dc.identifier.affiliationRoyal Melbourne Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.doi10.1136/jnnp-2018-319396en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-0992-1917en_US
dc.identifier.orcid0000-0002-2872-1112en_US
dc.identifier.orcid0000-0002-1750-5131en_US
dc.identifier.orcid0000-0002-6225-7739en_US
dc.identifier.orcid0000-0003-4580-841Xen_US
dc.identifier.pubmedid30796132-
dc.type.austinJournal Article-
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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