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dc.contributor.authorBuyck, Pieter-Jan-
dc.contributor.authorZuurbier, Susanna M-
dc.contributor.authorGarcia-Esperon, Carlos-
dc.contributor.authorBarboza, Miguel A-
dc.contributor.authorCosta, Paolo-
dc.contributor.authorEscudero, Irene-
dc.contributor.authorRenard, Dimitri-
dc.contributor.authorLemmens, Robin-
dc.contributor.authorHinteregger, Nicole-
dc.contributor.authorFazekas, Franz-
dc.contributor.authorConde, Jordi Jimenez-
dc.contributor.authorGiralt-Steinhauer, Eva-
dc.contributor.authorHiltunen, Sini-
dc.contributor.authorArauz, Antonio-
dc.contributor.authorPezzini, Alessandro-
dc.contributor.authorMontaner, Joan-
dc.contributor.authorPutaala, Jukka-
dc.contributor.authorWeimar, Christian-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorGattringer, Thomas-
dc.contributor.authorAsadi, Hamed-
dc.contributor.authorTatlisumak, Turgut-
dc.contributor.authorCoutinho, Jonathan M-
dc.contributor.authorDemaerel, Philippe-
dc.contributor.authorThijs, Vincent N-
dc.identifier.citationNeurology 2019; 92(8): e841-e851en
dc.description.abstractTo assess the added diagnostic value of semiquantitative imaging markers on noncontrast CT scans in cerebral venous thrombosis (CVT). In a retrospective, multicenter, blinded, case-control study of patients with recent onset (<2 weeks) CVT, 3 readers assessed (1) the accuracy of the visual impression of CVT based on a combination of direct and indirect signs, (2) the accuracy of attenuation values of the venous sinuses in Hounsfield units (with adjustment for hematocrit levels), and (3) the accuracy of attenuation ratios of affected vs unaffected sinuses in comparison with reference standard MRI or CT angiography. Controls were age-matched patients with (sub)acute neurologic presentations. We enrolled 285 patients with CVT and 303 controls from 10 international centers. Sensitivity of visual impression of thrombosis ranged from 41% to 73% and specificity ranged from 97% to 100%. Attenuation measurement had an area under the curve (AUC) of 0.78 (95% confidence interval [CI] 0.74-0.81). After adjustment for hematocrit, the AUC remained 0.78 (95% CI 0.74-0.81). The analysis of attenuation ratios of affected vs unaffected sinuses had AUC of 0.83 (95% CI 0.8-0.86). Adding this imaging marker significantly improved discrimination, but sensitivity when tolerating a false-positive rate of 20% was not higher than 76% (95% CI 0.70-0.81). Semiquantitative analysis of attenuation values for diagnosis of CVT increased sensitivity but still failed to identify 1 out of 4 CVT. This study provides Class II evidence that visual analysis of plain CT with or without attenuation measurements has high specificity but only moderate sensitivity for CVT.-
dc.titleDiagnostic accuracy of noncontrast CT imaging markers in cerebral venous thrombosis.-
dc.typeJournal Article-
dc.identifier.affiliationDepartment of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven-University of Leuvenen
dc.identifier.affiliationDepartment of Neurology, University Hospital Essen, Germanyen
dc.identifier.affiliationStroke Department, Instituto Nacional de Neurología y Neurocirugía Dr. Manuel Velasco Suárez, México City, Méxicoen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, University of Melbourneen
dc.identifier.affiliationAustralia School of Medicine, Faculty of Health, Deakin Universityen
dc.identifier.affiliationInterventional Neuroradiology Service, Radiology Department, Monash Health, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Clinical Neuroscience/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburgen
dc.identifier.affiliationDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Swedenen
dc.identifier.affiliationStroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelbergen
dc.identifier.affiliationLaboratory of Neurobiology, Center for Brain & Disease Research, VIB, Leuven, Belgiumen
dc.identifier.affiliationDepartments of Radiology and Neurology , Medical University of Graz, Austriaen
dc.identifier.affiliationDepartment of Neurology , Neurovascular Research Group, IMIM-Hospital del Mar, Barcelonaen
dc.identifier.affiliationUniversitat Autònoma de Barcelona, Spainen
dc.identifier.affiliationDepartment of Neurology, Helsinki University Hospital, Finlanden
dc.identifier.affiliationDepartment of Neurology, Hospital Universitario Virgen Macarena, Seville, Spainen
dc.identifier.affiliationDepartment of Head and Neck, Neurology Unit, Fondazione Poliambulanza, Brescia, Italyen
dc.identifier.affiliationDepartments of Head and Neck and Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Italyen
dc.identifier.affiliationNeurology Department , University Hospitals Virgen del Rocio and Macarena, Sevilleen
dc.identifier.affiliationNeurovascular Lab, Instituto de Biomedicina de Sevilla, Spainen
dc.identifier.affiliationDepartment of Neurology, Nîmes University Hospital, Franceen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartments of Radiology and Neurology, University Hospitals Leuven, Belgiumen
dc.identifier.affiliationDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam, the Netherlandsen
dc.identifier.affiliationDepartment of Neurology, John Hunter Hospital, University of Newcastle, Australiaen
dc.identifier.affiliationInterventional Neuroradiology Service, Department of Radiology, Austin Health, Heidelberg, Victoria, Australia-
dc.type.austinJournal Article-, Hamed
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en- (University of Melbourne)- Florey Institute of Neuroscience and Mental Health- Florey Institute of Neuroscience and Mental Health-
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