Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20085
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dc.contributor.authorCahill, Varduhi-
dc.contributor.authorSinclair, Benjamin-
dc.contributor.authorMalpas, Charles B-
dc.contributor.authorMcIntosh, Anne M-
dc.contributor.authorChen, Zhibin-
dc.contributor.authorVivash, Lucy E-
dc.contributor.authorO'Shea, Marie F-
dc.contributor.authorWilson, Sarah J-
dc.contributor.authorDesmond, Patricia M-
dc.contributor.authorBerlangieri, Salvatore U-
dc.contributor.authorHicks, Rodney J-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorMorokoff, Andrew P-
dc.contributor.authorKing, James A-
dc.contributor.authorFabinyi, Gavin C-
dc.contributor.authorKaye, Andrew H-
dc.contributor.authorKwan, Patrick-
dc.contributor.authorBerkovic, Samuel F-
dc.contributor.authorO'Brien, Terence J-
dc.date2019-
dc.date.accessioned2019-01-18T04:19:40Z-
dc.date.available2019-01-18T04:19:40Z-
dc.date.issued2019-01-04-
dc.identifier.citationAnnals of neurology 2019; 85(2): 241-250en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20085-
dc.description.abstractWe investigated the relationship between the interictal metabolic patterns, the extent of resection of 18 F-fluorodeoxyglucose positron emission tomography (18 FDG-PET) hypometabolism, and seizure outcomes in patients with unilateral drug-resistant mesial temporal lobe epilepsy (MTLE) following anterior temporal lobe (TL) resection. Eighty-two patients with hippocampal sclerosis or normal magnetic resonance imaging (MRI) findings, concordant 18 FDG-PET hypometabolism, and at least 2 years of postoperative follow-up were included in this 2-center study. The hypometabolic regions in each patient were identified with reference to 20 healthy controls (p < 0.005). The resected TL volume and the volume of resected TL PET hypometabolism (TLH) were calculated from the pre- and postoperative MRI scans coregistered with interictal 18 FDG-PET. Striking differences in metabolic patterns were observed depending on the lateralization of the epileptogenic TL. The extent of the ipsilateral TLH was significantly greater in left MTLE patients (p < 0.001), whereas right MTLE patients had significantly higher rates of contralateral (CTL) TLH (p = 0.016). In right MTLE patients, CTL hypometabolism was the strongest predictor of an unfavorable seizure outcome, associated with a 5-fold increase in the likelihood of seizure recurrence (odds ratio [OR] = 4.90, 95% confidence interval [CI] = 1.07-22.39, p = 0.04). In left MTLE patients, greater extent of resection of ipsilateral TLH was associated with lower rates of seizure recurrence (p = 0.004) in univariate analysis; however, its predictive value did not reach statistical significance (OR = 0.96, 95% CI = 0.90-1.02, p = 0.19). The difference in metabolic patterns depending on the lateralization of MTLE may represent distinct epileptic networks in patients with right versus left MTLE, and can guide preoperative counseling and surgical planning. Ann Neurol 2019; 1-10.en
dc.language.isoeng-
dc.titleMetabolic patterns and seizure outcomes following anterior temporal lobectomy.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnnals of neurologyen
dc.identifier.affiliationManchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, United Kingdomen
dc.identifier.affiliationDepartments of Medicine and Radiology, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMurdoch Children's Research Institute, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartments of Medicine and Neurology, Melbourne Brain Centre, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartments of Neuroscience and Neurology, Alfred Health, Central Clinical School, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationComprehensive Epilepsy Program, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationPeter MacCallum Cancer Centre and the Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Manchester, United Kingdomen
dc.identifier.doi10.1002/ana.25405en
dc.type.contentTexten
dc.identifier.orcid0000-0003-4580-841Xen
dc.identifier.orcid0000-0003-3910-2453en
dc.identifier.pubmedid30609109-
dc.type.austinJournal Article-
local.name.researcherBerkovic, Samuel F
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptClinical Neuropsychology-
crisitem.author.deptClinical Haematology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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