Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/20073
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lasica, Masa | - |
dc.contributor.author | Willcox, Abbey | - |
dc.contributor.author | Burbury, Kate | - |
dc.contributor.author | Ross, David M | - |
dc.contributor.author | Branford, Susan | - |
dc.contributor.author | Butler, Jason | - |
dc.contributor.author | Filshie, Robin | - |
dc.contributor.author | Januszewicz, Henry | - |
dc.contributor.author | Joske, David | - |
dc.contributor.author | Mills, Anthony | - |
dc.contributor.author | Simpson, David | - |
dc.contributor.author | Tam, Constantine | - |
dc.contributor.author | Taylor, Kerry | - |
dc.contributor.author | Watson, Anne-Marie | - |
dc.contributor.author | Wolf, Max | - |
dc.contributor.author | Grigg, Andrew P | - |
dc.date | 2019-01-11 | - |
dc.date.accessioned | 2019-01-18T04:19:39Z | - |
dc.date.available | 2019-01-18T04:19:39Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | Leukemia & lymphoma 2019; 60(7): 1796-1802 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/20073 | - |
dc.description.abstract | The management of CML in pregnancy is challenging with the need to balance disease control against potential teratogenic effects of TKI therapy. In this multi-center case-cohort study of 16 women in chronic phase, CML ceased TKI treatment pre- or post-conception during their first pregnancy. Thirteen patients were on imatinib; 9 ceased their TKI prior to conception and 7 ceased at pregnancy confirmation. Twelve patients had achieved either MMR or better at time of TKI cessation. Eleven women lost MMR during pregnancy and two patients lost CHR. Fourteen women reestablished MMR on TKI recommenced. The depth molecular response prior to conception appeared to correlate well with restoration of disease control on TKI recommencement though duration of MMR did not appear to be as important. While interruption of TKI treatment for pregnancy usually leads to loss of molecular response, loss of hematological response is uncommon and disease control is reestablished with resumption of therapy in the majority of women. | - |
dc.language.iso | eng | - |
dc.subject | Chronic myeloid leukemia | - |
dc.subject | dasatinib | - |
dc.subject | imatinib | - |
dc.subject | nilotinib | - |
dc.subject | pregnancy | - |
dc.subject | tyrosine kinase inhibitor | - |
dc.title | The effect of tyrosine kinase inhibitor interruption and interferon use on pregnancy outcomes and long-term disease control in chronic myeloid leukemia. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Leukemia & lymphoma | - |
dc.identifier.affiliation | Australian Centre for Blood Disease, Monash University, Melbourne, Australia | en |
dc.identifier.affiliation | St Vincent's Hospital, Fitzroy, Australia | en |
dc.identifier.affiliation | Royal Brisbane and Women's Hospital, Brisbane, Australia | en |
dc.identifier.affiliation | Centre for Cancer Biology, an alliance between SA Pathology and University of South Australia, Adelaide, Australia | en |
dc.identifier.affiliation | Bedford Park, Flinders University and Medical Centre, Adelaide Australia | en |
dc.identifier.affiliation | Department of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Peter MacCallum Cancer Centre, East Melbourne, Australia | en |
dc.identifier.affiliation | Icon Cancer Care, Mater Medical Centre, South Brisbane, Australia | en |
dc.identifier.affiliation | Ramsay Specialist Centre, Greenslopes Private Hospital, Greenslopes, Australia | en |
dc.identifier.affiliation | Sir Charles Gairdner Hospital, Nedlands, Australia | en |
dc.identifier.affiliation | North Shore Hospital, Waitemata District Health Board, Auckland, New Zealand | en |
dc.identifier.affiliation | Liverpool Hospital, Liverpool, Australia | en |
dc.identifier.doi | 10.1080/10428194.2018.1551533 | - |
dc.identifier.orcid | 0000-0002-9343-542X | - |
dc.identifier.orcid | 0000-0001-7171-2935 | - |
dc.identifier.pubmedid | 30632843 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Grigg, Andrew P | |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Clinical Haematology | - |
crisitem.author.dept | Olivia Newton-John Cancer Wellness and Research Centre | - |
crisitem.author.dept | Clinical Haematology | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.