Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20073
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dc.contributor.authorLasica, Masa-
dc.contributor.authorWillcox, Abbey-
dc.contributor.authorBurbury, Kate-
dc.contributor.authorRoss, David M-
dc.contributor.authorBranford, Susan-
dc.contributor.authorButler, Jason-
dc.contributor.authorFilshie, Robin-
dc.contributor.authorJanuszewicz, Henry-
dc.contributor.authorJoske, David-
dc.contributor.authorMills, Anthony-
dc.contributor.authorSimpson, David-
dc.contributor.authorTam, Constantine-
dc.contributor.authorTaylor, Kerry-
dc.contributor.authorWatson, Anne-Marie-
dc.contributor.authorWolf, Max-
dc.contributor.authorGrigg, Andrew P-
dc.date2019-01-11-
dc.date.accessioned2019-01-18T04:19:39Z-
dc.date.available2019-01-18T04:19:39Z-
dc.date.issued2019-07-
dc.identifier.citationLeukemia & lymphoma 2019; 60(7): 1796-1802-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20073-
dc.description.abstractThe management of CML in pregnancy is challenging with the need to balance disease control against potential teratogenic effects of TKI therapy. In this multi-center case-cohort study of 16 women in chronic phase, CML ceased TKI treatment pre- or post-conception during their first pregnancy. Thirteen patients were on imatinib; 9 ceased their TKI prior to conception and 7 ceased at pregnancy confirmation. Twelve patients had achieved either MMR or better at time of TKI cessation. Eleven women lost MMR during pregnancy and two patients lost CHR. Fourteen women reestablished MMR on TKI recommenced. The depth molecular response prior to conception appeared to correlate well with restoration of disease control on TKI recommencement though duration of MMR did not appear to be as important. While interruption of TKI treatment for pregnancy usually leads to loss of molecular response, loss of hematological response is uncommon and disease control is reestablished with resumption of therapy in the majority of women.-
dc.language.isoeng-
dc.subjectChronic myeloid leukemia-
dc.subjectdasatinib-
dc.subjectimatinib-
dc.subjectnilotinib-
dc.subjectpregnancy-
dc.subjecttyrosine kinase inhibitor-
dc.titleThe effect of tyrosine kinase inhibitor interruption and interferon use on pregnancy outcomes and long-term disease control in chronic myeloid leukemia.-
dc.typeJournal Article-
dc.identifier.journaltitleLeukemia & lymphoma-
dc.identifier.affiliationAustralian Centre for Blood Disease, Monash University, Melbourne, Australiaen
dc.identifier.affiliationSt Vincent's Hospital, Fitzroy, Australiaen
dc.identifier.affiliationRoyal Brisbane and Women's Hospital, Brisbane, Australiaen
dc.identifier.affiliationCentre for Cancer Biology, an alliance between SA Pathology and University of South Australia, Adelaide, Australiaen
dc.identifier.affiliationBedford Park, Flinders University and Medical Centre, Adelaide Australiaen
dc.identifier.affiliationDepartment of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationPeter MacCallum Cancer Centre, East Melbourne, Australiaen
dc.identifier.affiliationIcon Cancer Care, Mater Medical Centre, South Brisbane, Australiaen
dc.identifier.affiliationRamsay Specialist Centre, Greenslopes Private Hospital, Greenslopes, Australiaen
dc.identifier.affiliationSir Charles Gairdner Hospital, Nedlands, Australiaen
dc.identifier.affiliationNorth Shore Hospital, Waitemata District Health Board, Auckland, New Zealanden
dc.identifier.affiliationLiverpool Hospital, Liverpool, Australiaen
dc.identifier.doi10.1080/10428194.2018.1551533-
dc.identifier.orcid0000-0002-9343-542X-
dc.identifier.orcid0000-0001-7171-2935-
dc.identifier.pubmedid30632843-
dc.type.austinJournal Article-
local.name.researcherGrigg, Andrew P
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptClinical Haematology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptClinical Haematology-
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