Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20034
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dc.contributor.authorAlhusaini, Saud-
dc.contributor.authorKowalczyk, Magdalena A-
dc.contributor.authorYasuda, Clarissa L-
dc.contributor.authorSemmelroch, Mira K-
dc.contributor.authorKatsurayama, Marilise-
dc.contributor.authorZabin, Matheus-
dc.contributor.authorZanão, Tamires-
dc.contributor.authorNogueira, Mateus H-
dc.contributor.authorAlvim, Marina K M-
dc.contributor.authorFerraz, Victória R-
dc.contributor.authorTsai, Meng-Han-
dc.contributor.authorFitzsimons, Mary-
dc.contributor.authorLopes-Cendes, Iscia-
dc.contributor.authorDoherty, Colin P-
dc.contributor.authorCavalleri, Gianpiero L-
dc.contributor.authorCendes, Fernando-
dc.contributor.authorJackson, Graeme D-
dc.contributor.authorDelanty, Norman-
dc.date2018-12-26-
dc.date.accessioned2019-01-02T01:15:09Z-
dc.date.available2019-01-02T01:15:09Z-
dc.date.issued2019-
dc.identifier.citationNeurology 2019; 92(4): e351-e358-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20034-
dc.description.abstractTo examine cerebral cortex thickness in asymptomatic first-degree relatives of patients with mesial temporal lobe epilepsy (MTLE). We investigated 127 asymptomatic first-degree relatives of patients with MTLE due to hippocampal sclerosis (HS) (mean age ± SD = 39.4 ± 13 years) and 203 healthy control individuals (mean age ± SD = 36.0 ± 11 years). Participants underwent a comprehensive clinical evaluation and structural brain MRI at 3 study sites. Images were processed simultaneously at each site using a surface-based morphometry method to quantify global brain measures, hippocampal volumes, and cerebral cortical thickness. Differences in brain measures between relatives of patients and controls were examined using generalized models, while controlling for relevant covariates, including age and sex. None of the asymptomatic first-degree relatives of MTLE + HS patients showed evidence of HS on qualitative image assessments. Compared to the healthy controls, the asymptomatic relatives of patients displayed no significant differences in intracranial volume, average hemispheric surface area, or hippocampal volume. Similarly, no significant cerebral cortical thinning was identified in the relatives of patients. This was consistent across the 3 cohorts. Lack of cortical thickness changes in the asymptomatic relatives of patients indicates that the previously characterized MTLE + HS-related cortical thinning is not heritable, and is likely driven by disease-related factors. This finding therefore argues for early and aggressive intervention in patients with medically intractable epilepsy.-
dc.language.isoeng-
dc.titleNormal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients.-
dc.typeJournal Article-
dc.identifier.journaltitleNeurology-
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationBrain Morphometry Laboratory and Division of Neurology, Beaumont Hospital, Dublin, Irelanden
dc.identifier.affiliationDepartment of Neurology, St James's Hospital, Dublin, Irelanden
dc.identifier.affiliationFrom the Department of Molecular and Cellular Therapeutics and FutureNeuro Research Centre, the Royal College of Surgeons in Ireland, Dublinen
dc.identifier.affiliationDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Canadaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationNeuroimaging Laboratory, Department of Neurology, University of Campinas, São Paulo, Brazilen
dc.identifier.affiliationDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwanen
dc.identifier.doi10.1212/WNL.0000000000006834-
dc.identifier.pubmedid30587513-
dc.type.austinJournal Article-
local.name.researcherJackson, Graeme D
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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