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dc.contributor.authorO'Brien, Zachary-
dc.contributor.authorCass, Alan-
dc.contributor.authorCole, Louise-
dc.contributor.authorFinfer, Simon-
dc.contributor.authorGallagher, Martin-
dc.contributor.authorMcArthur, Colin-
dc.contributor.authorMcGuiness, Shay-
dc.contributor.authorMyburgh, John-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorMårtensson, Johan-
dc.identifier.citationJournal of Critical Care 2019; 49: 70-76-
dc.description.abstractTo investigate the relationship between sex and mortality and whether menopause or the intensity of renal replacement therapy (RRT) modify this relationship in patients with severe septic acute kidney injury (AKI). Post-hoc analysis of patients with sepsis included in the Randomized Evaluation of Normal versus Augmented Level renal replacement therapy (RENAL) trial. Of 724 patients, 458 (63.3%) were male and 266 (36.7%) were female. The mean delivered effluent flow rate was 25.6 ± 7.4 ml/kg/h (80 ± 15% of prescribed dose) in males and 27.4 ± 7.6 ml/kg/h (83 ± 15% of prescribed dose) in females (p = .01). A total of 237 (51.7%) males and 118 (44.5%) females died within 90 days of randomization (p = .06). The adjusted hazard ratio (HR) for 90-day mortality was significantly decreased in females as compared with males (HR 0.74, 95% CI 0.57 to 0.96, p = .02). The relationship between sex and mortality was not significantly altered by menopausal status (adjusted P value for interaction 0.99) or by RRT intensity allocation (adjusted P value for interaction 0.27). In a cohort of patients with sepsis and severe AKI, female sex was associated with improved survival. The relationship between sex and survival was not altered by menopausal status or RRT intensity.-
dc.subjectAcute kidney injury-
dc.subjectRenal replacement therapy-
dc.titleSex and mortality in septic severe acute kidney injury.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of Critical Care-
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSt George Clinical School, University of New South Wales, Sydney, NSW, Australiaen
dc.identifier.affiliationDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Swedenen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationCardiovascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealanden
dc.identifier.affiliationMenzies School of Health Research, Charles Darwin University, Darwin, Winnellie, NT, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Nepean Hospital, Sydney, Australiaen
dc.identifier.affiliationThe George Institute for Global Health, University of Sydney, Level 13, Sydney, NSW, Australiaen
dc.identifier.affiliationDepartment of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealanden
dc.type.austinJournal Article-, Rinaldo
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications- Care- Care- Analytics Research and Evaluation (DARE) Centre-
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