Joie, Renaud La; Ayakta, Nagehan; Seeley, William W; Borys, Ewa; Boxer, Adam L; DeCarli, Charles; Doré, Vincent; Grinberg, Lea T; Huang, Eric; Hwang, Ji-Hye; Ikonomovic, Milos D; Jack, Clifford; Jagust, William J; Jin, Lee-Way; Klunk, William E; Kofler, Julia; Lesman-Segev, Orit H; Lockhart, Samuel N; Lowe, Val J; Masters, Colin L; Mathis, Chester A; McLean, Catriona L; Miller, Bruce L; Mungas, Daniel; O'Neil, James P; Olichney, John M; Parisi, Joseph E; Petersen, Ronald C; Rosen, Howard J; Rowe, Christopher C; Spina, Salvatore; Vemuri, Prashanthi; Villemagne, Victor L; Murray, Melissa E; Rabinovici, Gil D

doi:10.1016/j.jalz.2018.09.001

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.

Author(s)

Joie, Renaud La

Ayakta, Nagehan

Seeley, William W

Borys, Ewa

Boxer, Adam L

DeCarli, Charles

Doré, Vincent

Grinberg, Lea T

Huang, Eric

Hwang, Ji-Hye

Ikonomovic, Milos D

Jack, Clifford

Jagust, William J

Jin, Lee-Way

Klunk, William E

Kofler, Julia

Lesman-Segev, Orit H

Lockhart, Samuel N

Lowe, Val J

Masters, Colin L

Mathis, Chester A

McLean, Catriona L

Miller, Bruce L

Mungas, Daniel

O'Neil, James P

Olichney, John M

Parisi, Joseph E

Petersen, Ronald C

Rosen, Howard J

Rowe, Christopher C

Spina, Salvatore

Vemuri, Prashanthi

Villemagne, Victor L

Murray, Melissa E

Rabinovici, Gil D

Publication Date

2019

Abstract

We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [11C]PIB-positron emission tomography ([11C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ-PET quantification. Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings. CL values increased with each CERAD neuritic plaque score increment (median -3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases. Findings were comparable across sites and when restricted to 56 patients who died within 2 years of PET. A threshold of 12.2 CL detected CERAD moderate-to-frequent neuritic plaques (area under the curve = 0.910, sensitivity = 89.2%, specificity = 86.4%), whereas 24.4 CL identified intermediate-to-high AD neuropathological changes (area under the curve = 0.894, sensitivity = 84.1%, specificity = 87.9%). Our study demonstrated the robustness of a multisite Centiloid [11C]PIB-PET study and established a range of pathology-based CL thresholds.

Citation

Alzheimer's & dementia : the journal of the Alzheimer's Association 2019; 15(2): 205-216

Jornal Title

Alzheimer's & dementia : the journal of the Alzheimer's Association

OrcId

0000-0003-3910-2453

Link

https://ahro.austin.org.au/austinjspui/handle/1/19766

Subject

Alzheimer's disease neuropathologic changes

CERAD

Centiloid

Harmonization

Neuropathology

Pittsburgh compound-B

Positron emission tomography

Thal

Threshold

β-amyloid

Title

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.

Type of document

Journal Article

Austin Health

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.

Files:

Author(s)	Joie, Renaud La Ayakta, Nagehan Seeley, William W Borys, Ewa Boxer, Adam L DeCarli, Charles Doré, Vincent Grinberg, Lea T Huang, Eric Hwang, Ji-Hye Ikonomovic, Milos D Jack, Clifford Jagust, William J Jin, Lee-Way Klunk, William E Kofler, Julia Lesman-Segev, Orit H Lockhart, Samuel N Lowe, Val J Masters, Colin L Mathis, Chester A McLean, Catriona L Miller, Bruce L Mungas, Daniel O'Neil, James P Olichney, John M Parisi, Joseph E Petersen, Ronald C Rosen, Howard J Rowe, Christopher C Spina, Salvatore Vemuri, Prashanthi Villemagne, Victor L Murray, Melissa E Rabinovici, Gil D
Publication Date	2019
Abstract	We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [11C]PIB-positron emission tomography ([11C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ-PET quantification. Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings. CL values increased with each CERAD neuritic plaque score increment (median -3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases. Findings were comparable across sites and when restricted to 56 patients who died within 2 years of PET. A threshold of 12.2 CL detected CERAD moderate-to-frequent neuritic plaques (area under the curve = 0.910, sensitivity = 89.2%, specificity = 86.4%), whereas 24.4 CL identified intermediate-to-high AD neuropathological changes (area under the curve = 0.894, sensitivity = 84.1%, specificity = 87.9%). Our study demonstrated the robustness of a multisite Centiloid [11C]PIB-PET study and established a range of pathology-based CL thresholds.
Citation	Alzheimer's & dementia : the journal of the Alzheimer's Association 2019; 15(2): 205-216
Jornal Title	Alzheimer's & dementia : the journal of the Alzheimer's Association
OrcId	0000-0003-3910-2453
Link	https://ahro.austin.org.au/austinjspui/handle/1/19766
Subject	Alzheimer's disease neuropathologic changes CERAD Centiloid Harmonization Neuropathology Pittsburgh compound-B Positron emission tomography Thal Threshold β-amyloid
Title	Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.
Type of document	Journal Article