Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/19695
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DC Field | Value | Language |
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dc.contributor.author | Salem, Mohamed E | - |
dc.contributor.author | Yin, Jun | - |
dc.contributor.author | Weinberg, Benjamin A | - |
dc.contributor.author | Renfro, Lindsay A | - |
dc.contributor.author | Pederson, Levi D | - |
dc.contributor.author | Maughan, Timothy S | - |
dc.contributor.author | Adams, Richard A | - |
dc.contributor.author | Van Cutsem, Eric | - |
dc.contributor.author | Falcone, Alfredo | - |
dc.contributor.author | Tebbutt, Niall C | - |
dc.contributor.author | Seymour, Matthew T | - |
dc.contributor.author | Díaz-Rubio, Eduardo | - |
dc.contributor.author | Aranda, Enrique | - |
dc.contributor.author | Bokemeyer, Carsten | - |
dc.contributor.author | Heinemann, Volker | - |
dc.contributor.author | Wasan, Harpreet | - |
dc.contributor.author | de Gramont, Aimery | - |
dc.contributor.author | Grothey, Axel | - |
dc.contributor.author | Shi, Qian | - |
dc.contributor.author | Sargent, Daniel J | - |
dc.contributor.author | Marshall, John L | - |
dc.date | 2018-09-27 | - |
dc.date.accessioned | 2018-10-23T22:28:43Z | - |
dc.date.available | 2018-10-23T22:28:43Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.citation | European journal of cancer (Oxford, England : 1990) 2018; 103: 205-213 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/19695 | - |
dc.description.abstract | Patients with left-sided colon tumours have better survival and respond differently to biologics compared with patients with right-sided tumours. Left-sided colon tumours and rectal cancers are often grouped together. Herein, we examined the clinicopathological differences and outcomes between left-sided colon and rectal cancers. Data from 2879 metastatic colorectal cancer patients enrolled on six first-line clinical trials during 2004-2010 were pooled. Patients were included if the primary tumour origin was clearly defined. Progression-free survival (PFS) and overall survival (OS) were compared in the two groups after adjusting for patient and tumour characteristics, metastatic sites and the first-line regimen. In total, 1374 patients with metastatic left-sided colon cancer and 1505 patients with metastatic rectal cancers were evaluated. Left-sided colon cancer patients were more likely to be female (40.1% versus 32.6%; P < 0.0001) and older (31.0% ≥ 70 years versus 25.8%; P = 0.0033) compared with rectal cancers patients. Patients with left-sided colon cancer had higher rates of liver metastases (80.9% versus 72.3%, P < 0.0001) but lower rates of lung metastases (34.2% versus 53.8%, P < 0.0001). KRAS mutations were slightly less frequent among left-sided tumours (34.8% versus 40.5%; P = 0.0103). Patients with left-sided tumours had approximately similar PFS (median 7.4 versus 6.9 months; hazard ratio [HR] 0.92, 95% confidence interval [CI] 0.87-1.03; P = 0.1998) and OS (median 17.4 versus 16.6 months; HR 0.99, 95% CI 0.91-1.07; P = 0.7597) compared with rectal cancer patients. The site of tumour origin within the left side was not prognostic of outcomes. Moreover, neither bevacizumab nor cetuximab impacted, differently, the findings of the comparisons in outcomes between patients with left-sided colon tumours or rectal cancers. | - |
dc.language.iso | eng | - |
dc.subject | Bevacizumab | - |
dc.subject | Cetuximab | - |
dc.subject | Left-sided colon cancer | - |
dc.subject | Outcomes | - |
dc.subject | Rectal cancer | - |
dc.title | Clinicopathological differences and survival outcomes with first-line therapy in patients with left-sided colon cancer and rectal cancer: Pooled analysis of 2879 patients from AGITG (MAX), COIN, FOCUS2, OPUS, CRYSTAL and COIN-B trials in the ARCAD database. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | European journal of cancer (Oxford, England : 1990) | - |
dc.identifier.affiliation | Medical Oncology, West Cancer Center, Germantown, TN, USA | en |
dc.identifier.affiliation | Imperial College Healthcare NHS Trust, London, UK | en |
dc.identifier.affiliation | Department of Medical Oncology, Franco-British Institute, Levallois-Perret, France | en |
dc.identifier.affiliation | Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA | en |
dc.identifier.affiliation | Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA | en |
dc.identifier.affiliation | Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA | en |
dc.identifier.affiliation | CRUK/MRC Oxford Institute for Radiation Oncology, Oxford, UK | en |
dc.identifier.affiliation | Cardiff University, Cardiff, UK | en |
dc.identifier.affiliation | Digestive Oncology, University Hospitals Leuven and KU Leuven, Leuven, Belgium | en |
dc.identifier.affiliation | Department of Oncology, University of Pisa, Pisa, Italy | en |
dc.identifier.affiliation | Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Gastrointestinal Cancer Research Unit, Cookridge Hospital, Leeds, UK | en |
dc.identifier.affiliation | Department Oncology, Hospital Clínico San Carlos, CIBERONC, Madrid, Spain | en |
dc.identifier.affiliation | Reina Sofia Hospital, University of Cordoba, Maimonides Institute of Biomedical Research, CIBERONC, Avenida de Menendez Pidal, Cordoba, Spain | en |
dc.identifier.affiliation | Department of Oncology, Haematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany | en |
dc.identifier.affiliation | Comprehensive Cancer Center, Ludwig-Maximilians-University of Munich, Munich, Germany | en |
dc.identifier.doi | 10.1016/j.ejca.2018.08.020 | - |
dc.identifier.pubmedid | 30268921 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Tebbutt, Niall C | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Medical Oncology | - |
crisitem.author.dept | Olivia Newton-John Cancer Wellness and Research Centre | - |
Appears in Collections: | Journal articles |
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