Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19674
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dc.contributor.authorOng, Wee Loon-
dc.contributor.authorForoudi, Farshad-
dc.contributor.authorEvans, Sue-
dc.contributor.authorMillar, Jeremy-
dc.date2018-10-08-
dc.date.accessioned2018-10-23T22:28:41Z-
dc.date.available2018-10-23T22:28:41Z-
dc.date.issued2018-10-08-
dc.identifier.citationJournal of Medical Imaging and Radiation Oncology 2018; online first: 8 Octoberen_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19674-
dc.description.abstractThe aim of this study is to evaluate the use of androgen deprivation therapy (ADT) with post-prostatectomy radiotherapy (PPRT) in a population-based cohort of Australian men. This is a prospective cohort of men with localised prostate cancer captured in the Prostate Cancer Outcomes Registry Victoria (PCOR-Vic), who received PPRT between January 2010 and December 2015. The primary outcome was ADT use with PPRT. Multivariate logistic regressions were used to identify patient, tumour and institutional factors influencing ADT use. 485 men were included in this study - 115 (24%) had pT2 disease, 231 (48%) pT3a, 134 (28%) pT3b and 5 (1%) pT4. Eighteen (4%) men had ISUP grade 1 disease, 139 (29%) ISUP grade 2, 170 (35%) ISUP grade 3 and 158 (33%) ISUP grade 4/5, while 267 (64%) men had positive surgical margins. Median time from prostatectomy to PPRT was 8.1 months (IQR = 5.3-13.9). Sixty-six (14%) patients had ADT with PPRT. In multivariate analyses, men who had increased age (OR = 1.06; 95% CI = 1.01-1.11), seminal vesicle involvement (OR = 3.81; 95% CI = 1.63-8.91) and underwent treatment in regional centres (OR = 2.17; 95% CI = 1.08-4.33) were more likely to have ADT with PPRT. We reported that 14% of men treated with PPRT received ADT in a population-based cohort of Australian men, which was less than half of the proportion of ADT use with PPRT in the US. It will be of interest to evaluate the uptake of ADT with PPRT in the coming years following recent publications of level 1 evidence confirming overall survival benefits of ADT with PPRT.en_US
dc.language.isoeng-
dc.subjectAndrogen deprivationen_US
dc.subjectPost-prostatectomyen_US
dc.subjectProstate canceren_US
dc.subjectRadiotherapyen_US
dc.subjectRegistryen_US
dc.titleAndrogen deprivation therapy use with post-prostatectomy radiotherapy in the Prostate Cancer Outcomes Registry Victoria.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Medical Imaging and Radiation Oncologyen_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationCentral Clinical School, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationAlfred Health Radiation Oncology Services, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationRadiation Oncologyen_US
dc.identifier.affiliationDepartment of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationHealth and Biomedical Informatics Centre, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen_US
dc.identifier.doi10.1111/1754-9485.12818en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-6657-7193en_US
dc.identifier.orcid0000-0001-8387-0965en_US
dc.identifier.pubmedid30295411-
dc.type.austinJournal Article-
local.name.researcherForoudi, Farshad
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptRadiation Oncology-
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