Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19598
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dc.contributor.authorKhoo, Kaylyn-
dc.contributor.authorLew, Jeremy F-
dc.contributor.authorNeef, Pieter A-
dc.contributor.authorKearney, Leighton G-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorRobbins, Raymond J-
dc.contributor.authorTan, Alanna-
dc.contributor.authorHachem, M-
dc.contributor.authorOwen-Jones, L-
dc.contributor.authorLam, Que T-
dc.contributor.authorHart, Alanna-
dc.contributor.authorWilson, A-
dc.contributor.authorSumithran, Priya-
dc.contributor.authorJohnson, Douglas F-
dc.contributor.authorSrivastava, Piyush M-
dc.contributor.authorFarouque, Omar-
dc.contributor.authorBurrell, Louise M-
dc.contributor.authorZajac, Jeffrey D-
dc.contributor.authorEkinci, Elif I-
dc.date2018-09-10-
dc.date.accessioned2018-10-11T02:51:45Z-
dc.date.available2018-10-11T02:51:45Z-
dc.date.issued2018-09-10-
dc.identifier.citationScientific Reports 2018; 8(1): 13564en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19598-
dc.description.abstractDiabetes is an independent risk factor for development of heart failure and has been associated with poor outcomes in these patients. The prevalence of diabetes continues to rise. Using routine HbA1c measurements on inpatients at a tertiary hospital, we aimed to investigate the prevalence of diabetes amongst patients hospitalised with decompensated heart failure and the association of dysglycaemia with hospital outcomes and mortality. 1191 heart failure admissions were identified and of these, 49% had diabetes (HbA1c ≥ 6.5%) and 34% had pre-diabetes (HbA1c 5.7-6.4%). Using a multivariable analysis adjusting for age, Charlson comorbidity score (excluding diabetes and age) and estimated glomerular filtration rate, diabetes was not associated with length of stay (LOS), Intensive Care Unit (ICU) admission or 28-day readmission. However, diabetes was associated with a lower risk of 6-month mortality. This finding was also supported using HbA1c as a continuous variable. The diabetes group were more likely to have diastolic dysfunction and to be on evidence-based cardiac medications. These observational data are hypothesis generating and possible explanations include that more diabetic patients were on medications that have proven mortality benefit or prevent cardiac remodelling, such as renin-angiotensin system antagonists, which may modulate the severity of heart failure and its consequences.en_US
dc.language.isoeng-
dc.titleRoutine use of HbA1c amongst inpatients hospitalised with decompensated heart failure and the association of dysglycaemia with outcomes.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleScientific Reportsen_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationCardiologyen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationStrategy, Quality & Service Redesign, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationAustin Centre for Applied Clinical Informatics, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationPathologyen_US
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationHealth and Biomedical Informatics Centre, University of Melbourne, Parkville, 3010, Victoria, Australiaen_US
dc.identifier.affiliationSt Vincent's Hospital Melbourne, Fitzroy, 3065, Victoria, Australiaen_US
dc.identifier.affiliationGeneral Medicineen_US
dc.identifier.doi10.1038/s41598-018-31473-8en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-9807-6606en_US
dc.identifier.orcid0000-0003-1863-7539en_US
dc.identifier.orcid0000-0002-7143-7387en_US
dc.identifier.orcid0000-0003-2372-395Xen_US
dc.identifier.pubmedid30202020-
dc.type.austinJournal Article-
local.name.researcherBurrell, Louise M
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptCardiology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptClinical Analytics and Reporting-
crisitem.author.deptEndocrinology-
crisitem.author.deptPathology-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
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