Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19478
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dc.contributor.authorAdler, N R-
dc.contributor.authorAung, A K-
dc.contributor.authorErgen, E N-
dc.contributor.authorTrubiano, Jason-
dc.contributor.authorGoh, M S Y-
dc.contributor.authorPhillips, Elizabeth J-
dc.date2017-09-29-
dc.date.accessioned2018-09-17T01:47:16Z-
dc.date.available2018-09-17T01:47:16Z-
dc.date.issued2017-11-
dc.identifier.citationThe British journal of dermatology 2017; 177(5): 1234-1247-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19478-
dc.description.abstractSevere cutaneous adverse reactions (SCARs) encompass a heterogeneous group of delayed hypersensitivity reactions, which are most frequently caused by drugs. Our understanding of several aspects of SCAR syndromes has evolved considerably over the last decade. This review explores evolving knowledge of the immunopathogenic mechanisms, pharmacogenomic associations, in vivo and ex vivo diagnostics for causality assessment, and medication cross-reactivity data related to SCAR syndromes. Given the rarity and severity of these diseases, multidisciplinary collaboration through large international, national and/or multicentre networks to collect prospective data on patients with SCAR syndromes should be prioritized. This will further enhance a systematized framework for translating epidemiological, clinical and immunopathogenetic advances into preventive efforts and improved outcomes for patients.-
dc.language.isoeng-
dc.titleRecent advances in the understanding of severe cutaneous adverse reactions.-
dc.typeJournal Article-
dc.identifier.journaltitleThe British journal of dermatology-
dc.identifier.affiliationDepartment of Medicine, Vanderbilt University Medical Centre, Nashville, TN, U.S.A..en
dc.identifier.affiliationSchool of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia-
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationInstitute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australiaen
dc.identifier.affiliationDepartment of Dermatology, University of Alabama, Birmingham, AL, U.S.A-
dc.identifier.affiliationAlfred Hospital, Melbourne, Victoria, Australia-
dc.identifier.doi10.1111/bjd.15423-
dc.identifier.orcid0000-0002-7972-9050-
dc.identifier.pubmedid28256714-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherTrubiano, Jason-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
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