Lalic, Samanta; Jokanovic, Natali; Ilomäki, Jenni; Gisev, Natasa; Lloyd, Belinda; Lubman, Dan I; Bell, J Simon

doi:10.1016/j.sapharm.2018.07.001

Author(s)

Lalic, Samanta

Jokanovic, Natali

Ilomäki, Jenni

Gisev, Natasa

Lloyd, Belinda

Lubman, Dan I

Bell, J Simon

Publication Date

2019

Abstract

Evidence is accumulating globally on harms from extramedical prescription opioid analgesic (POA) use. The aim of this scoping review was to explore harms and documented risk factors associated with extramedical POA use in Australia. MEDLINE, EMBASE, PsycINFO and CINAHL were searched for original studies published between January 2000 and February 2018. Studies were eligible for inclusion if: 1) POA use was explicitly reported, 2) extramedical use was evident 3) harm was explicitly reported, 4) data were collected in/after 2000, 5) conducted in adults and 6) undertaken in Australia. We identified 560 articles and 16 met the inclusion criteria. Harms reported from extramedical POA use included: increased health service utilization (n = 5), non-fatal overdose (n = 6), fatal overdose (n = 5), injection-related injuries or diseases (n = 4), engagement in crime (n = 2), loss of employment (n = 1), and foreign body pulmonary embolization (n = 1). Multiple drug toxicity was reported as the cause of death in up to 83% of fatal overdose cases. Risk factors for harm included being male, aged 31-49 years, a history of chronic non-cancer pain, mental health disorders and/or substance abuse, and concomitant use of benzodiazepines, antidepressants or other centrally-acting substances. Extramedical use of POAs is associated with a range of harms, including fatal and non-fatal overdose. Polysubstance use with other centrally-acting substances was often implicated. No published studies used linked data sources to provide a comprehensive overview of the extent of POA use or harm in Australia. Future research should focus on undertaking longitudinal cohort studies with linked data sources.

Citation

Research in social & administrative pharmacy : RSAP 2019; 15(8): 925-935

Jornal Title

Research in social & administrative pharmacy : RSAP

OrcId

0000-0002-7055-3626

Link

https://ahro.austin.org.au/austinjspui/handle/1/19421

Subject

Australia

Drug overdose

Extramedical use

Harm

Opioid analgesics

Review

Title

Harms associated with extramedical use of prescription opioid analgesics in Australia: A scoping review.

Type of document

Journal Article

Austin Health

Harms associated with extramedical use of prescription opioid analgesics in Australia: A scoping review.

Files:

Author(s)	Lalic, Samanta Jokanovic, Natali Ilomäki, Jenni Gisev, Natasa Lloyd, Belinda Lubman, Dan I Bell, J Simon
Publication Date	2019
Abstract	Evidence is accumulating globally on harms from extramedical prescription opioid analgesic (POA) use. The aim of this scoping review was to explore harms and documented risk factors associated with extramedical POA use in Australia. MEDLINE, EMBASE, PsycINFO and CINAHL were searched for original studies published between January 2000 and February 2018. Studies were eligible for inclusion if: 1) POA use was explicitly reported, 2) extramedical use was evident 3) harm was explicitly reported, 4) data were collected in/after 2000, 5) conducted in adults and 6) undertaken in Australia. We identified 560 articles and 16 met the inclusion criteria. Harms reported from extramedical POA use included: increased health service utilization (n = 5), non-fatal overdose (n = 6), fatal overdose (n = 5), injection-related injuries or diseases (n = 4), engagement in crime (n = 2), loss of employment (n = 1), and foreign body pulmonary embolization (n = 1). Multiple drug toxicity was reported as the cause of death in up to 83% of fatal overdose cases. Risk factors for harm included being male, aged 31-49 years, a history of chronic non-cancer pain, mental health disorders and/or substance abuse, and concomitant use of benzodiazepines, antidepressants or other centrally-acting substances. Extramedical use of POAs is associated with a range of harms, including fatal and non-fatal overdose. Polysubstance use with other centrally-acting substances was often implicated. No published studies used linked data sources to provide a comprehensive overview of the extent of POA use or harm in Australia. Future research should focus on undertaking longitudinal cohort studies with linked data sources.
Citation	Research in social & administrative pharmacy : RSAP 2019; 15(8): 925-935
Jornal Title	Research in social & administrative pharmacy : RSAP
OrcId	0000-0002-7055-3626
Link	https://ahro.austin.org.au/austinjspui/handle/1/19421
Subject	Australia Drug overdose Extramedical use Harm Opioid analgesics Review
Title	Harms associated with extramedical use of prescription opioid analgesics in Australia: A scoping review.
Type of document	Journal Article