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dc.contributor.authorAmatoury, Jason-
dc.contributor.authorJordan, Amy S-
dc.contributor.authorToson, Barbara-
dc.contributor.authorNguyen, Chinh-
dc.contributor.authorWellman, Andrew-
dc.contributor.authorEckert, Danny J-
dc.identifier.citationSleep 2018; 41(11)-
dc.description.abstractA negative intrathoracic pressure threshold is one commonly proposed mechanism for triggering respiratory-induced arousals in obstructive sleep apnea (OSA). If so, they should occur during inspiration, shortly after maximal negative pressure swings. Alternatively, respiratory-induced arousals may occur throughout the respiratory cycle if other mechanisms also contribute. However, arousal timing has been minimally investigated. This study aimed to: 1) determine the temporal relationship between respiratory-induced arousals and breathing phase and 2) characterize neuromuscular and load compensation responses prior to arousal. 51 CPAP-treated OSA patients underwent a sleep physiology study with genioglossus and tensor palatini EMG, nasal mask/pneumotachograph and epiglottic pressure. Transient CPAP reductions were delivered to induce respiratory-related arousals. Of 354 arousals, 65(60-70)%[mean(CI)] occurred during inspiration, 35(30-40)% during expiration. Nadir epiglottic pressure occurred 68(66-69)% into inspiration, while inspiratory arousals had a uniform distribution throughout inspiration. Expiratory arousals occurred predominantly in early expiration. CPAP reductions initially reduced minute ventilation by ~2.5L/min, which was restored immediately prior to expiratory but not inspiratory arousals. Duty cycle just prior to arousal was greater for inspiratory versus expiratory arousals [0.20(0.18-0.21) vs. 0.13(0.11-0.15)Δbaseline, P=0.001]. Peak tensor palatini EMG was higher for expiratory versus inspiratory arousals during pre-arousal breaths [7.6(5.8-9.6) vs. 3.7(3.0-4.5)%Δbaseline, P=0.001], while genioglossus and tonic tensor palatini EMG were similar between arousal types. Over one third of respiratory-induced arousals occur during expiration. These findings highlight the importance of non-pressure threshold mechanisms of respiratory-induced arousals in OSA and suggest expiratory arousals may be a novel marker of enhanced tensor palatini neuromuscular compensation.-
dc.titleNew Insights into the Timing and Potential Mechanisms of Respiratory-Induced Cortical Arousals in Obstructive Sleep Apnea.-
dc.typeJournal Article-
dc.identifier.affiliationDivision of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAen
dc.identifier.affiliationBiomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture (MSFEA), American University of Beirut, Beirut, Lebanonen
dc.identifier.affiliationMelbourne School of Physiological Sciences, University of Melbourne, Melbourne,Heidelberg, Victoria, Australiaen
dc.identifier.affiliationNeuroscience Research Australia (NeuRA), Sydney, NSW, Australiaen
dc.identifier.affiliationSchool of Medical Sciences, University of New South Wales, Sydney, NSW, Australiaen
dc.identifier.affiliationInstitute for Breathing and Sleep and Austin Health, Heidelberg, Victoria, Australia-
dc.type.austinJournal Article-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- and Sleep Medicine- for Breathing and Sleep-
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