Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19344
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dc.contributor.authorNg Tang Fui, Mark-
dc.contributor.authorHoermann, Rudolf-
dc.contributor.authorGrossmann, Mathis-
dc.date2017-04-01-
dc.date.accessioned2018-09-16T23:53:55Z-
dc.date.available2018-09-16T23:53:55Z-
dc.date.issued2017-02-28-
dc.identifier.citationJournal of the Endocrine Society 2017; 1(4): 302-312en_US
dc.identifier.issn2472-1972-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19344-
dc.description.abstractIn obese men with lowered testosterone levels, testosterone treatment augments diet-associated loss of body fat. We hypothesized that testosterone treatment modulates circulating concentrations of hormonal mediators of fat mass and energy homeostasis in obese men undergoing a weight loss program. Prespecified secondary analysis of a randomized, double-blind, placebo-controlled trial. Tertiary referral center. Obese men (body mass index ≥30 kg/m2) with a repeated total testosterone level ≤12 nmol/L. One hundred participants mean age 53 years (interquartile range 47 to 60 years) receiving 10 weeks of a very low-energy diet followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of intramuscular testosterone undecanoate (cases, n = 49) or matching placebo (controls, n = 51). Eighty-two men completed the study. Between-group differences in leptin, adiponectin, ghrelin, glucagon like peptide-1, gastric inhibitory polypeptide, peptide YY, pancreatic polypeptide, and amylin levels. At study end, compared with controls, cases had greater reductions in leptin [mean adjusted difference (MAD), -3.6 ng/mL (95% CI, -5.3 to -1.9); P < 0.001]. The change in leptin levels between cases and controls was dependent on baseline fat mass, as the between-group difference progressively increased with increasing fat mass [MAD, -0.26 ng/mL (95% CI, -0.31 to -0.26); P = 0.001 per 1 kg of baseline fat mass]. Weight loss-associated changes in other hormones persisted during the weight maintenance phase but were not modified by testosterone treatment. Testosterone treatment led to reductions in leptin beyond those achieved by diet-associated weight loss. Testosterone treatment may reduce leptin resistance in obese men.en_US
dc.language.isoeng-
dc.subjectenergy homeostasisen_US
dc.subjectleptinen_US
dc.subjectobesityen_US
dc.subjecttestosteroneen_US
dc.titleEffect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of the Endocrine Societyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.doi10.1210/js.2017-00062en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-8261-3457en_US
dc.identifier.pubmedid29264488-
dc.type.austinJournal Article-
local.name.researcherGrossmann, Mathis
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
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