Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19230
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dc.contributor.authorWeinberg, Laurence-
dc.contributor.authorBroad, Jeremy-
dc.contributor.authorPillai, Parameswan-
dc.contributor.authorChen, Guangjun-
dc.contributor.authorNguyen, Micheline-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorScurrah, Nick-
dc.contributor.authorNikfarjam, Mehrdad-
dc.contributor.authorStory, David A-
dc.contributor.authorMcNicol, Larry-
dc.contributor.authorBellomo, Rinaldo-
dc.date2016-03-14-
dc.date.accessioned2018-09-13T00:21:14Z-
dc.date.available2018-09-13T00:21:14Z-
dc.date.issued2016-05-
dc.identifier.citationClinical transplantation 2016; 30(5): 556-65-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19230-
dc.description.abstractLiver transplantation-associated acute kidney injury (AKI) carries significant morbidity and mortality. We hypothesized that sodium bicarbonate would reduce the incidence and/or severity of liver transplantation-associated AKI. In this double-blinded pilot RCT, adult patients undergoing orthotopic liver transplantation were randomized to an infusion of either 8.4% sodium bicarbonate (0.5 mEq/kg/h for the first hour; 0.15 mEq/kg/h until completion of surgery); (n = 30) or 0.9% sodium chloride (n = 30). AKI within the first 48 h post-operatively. There were no significant differences between the two treatment groups with regard to baseline characteristics, model for end-stage liver disease and acute physiology and chronic health evaluation (APACHE) II scores, and pre-transplantation renal function. Intra-operative factors were similar for duration of surgery, blood product requirements, crystalloid and colloid volumes infused and requirements for vasoactive therapy. Eleven patients (37%) in the bicarbonate group and 10 patients (33%) in the sodium chloride group developed a post-operative AKI (p = 0.79). Bicarbonate infusion attenuated the degree of immediate post-operative metabolic acidosis; however, this effect dissipated by 48 h. There were no significant differences in ventilation hours, ICU or hospital length of stay, or mortality. The intra-operative infusion of sodium bicarbonate did not decrease the incidence of AKI in patients following orthotopic liver transplantation.-
dc.language.isoeng-
dc.subjectbicarbonate-
dc.subjectkidney injury-
dc.subjectliver transplantation-
dc.titleSodium bicarbonate infusion in patients undergoing orthotopic liver transplantation: a single center randomized controlled pilot trial.-
dc.typeJournal Article-
dc.identifier.journaltitleClinical transplantation-
dc.identifier.affiliationDepartment of Anesthesia,Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationCentre for Anesthesia, Perioperative and Pain Medicine, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationFaculty of Health, School of Nursing & Midwifery, Deakin University, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery and Centre for Anesthesia, Perioperative and Pain Medicine, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Anesthesiology, CHUM St-Luc Hospital, Montreal, QC, Canadaen
dc.identifier.affiliationFaculty of MN&HS, Monash University, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1111/ctr.12721-
dc.identifier.orcid0000-0001-7403-7680-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.orcid0000-0002-6479-1310-
dc.identifier.orcid0000-0003-4866-276X-
dc.identifier.pubmedid26915026-
dc.type.austinClinical Trial-
dc.type.austinClinical Trial, Phase II-
dc.type.austinJournal Article-
dc.type.austinRandomized Controlled Trial-
dc.type.austinResearch Support, Non-U.S. Gov't-
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptAnaesthesia-
crisitem.author.deptAnaesthesia-
crisitem.author.deptIntensive Care-
crisitem.author.deptAnaesthesia-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptAnaesthesia-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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