Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19123
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dc.contributor.authorHuber, Roman-
dc.contributor.authorGrittner, Ulrike-
dc.contributor.authorWeidemann, Frank-
dc.contributor.authorThijs, Vincent N-
dc.contributor.authorTanislav, Christian-
dc.contributor.authorEnzinger, Christian-
dc.contributor.authorFazekas, Franz-
dc.contributor.authorWolf, Markus-
dc.contributor.authorHennerici, Michael G-
dc.contributor.authorMcCabe, Dominick J H-
dc.contributor.authorPutaala, Jukaa-
dc.contributor.authorTatlisumak, Turgut-
dc.contributor.authorKessler, Christoph-
dc.contributor.authorvon Sarnowski, Bettina-
dc.contributor.authorMartus, Peter-
dc.contributor.authorKolodny, Edwin-
dc.contributor.authorNorrving, Bo-
dc.contributor.authorRolfs, Arndt-
dc.date2016-11-29-
dc.date.accessioned2018-09-13T00:21:04Z-
dc.date.available2018-09-13T00:21:04Z-
dc.date.issued2017-01-
dc.identifier.citationStroke 2017; 48(1): 30-35-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19123-
dc.description.abstractA patent foramen ovale (PFO) is disproportionately prevalent in patients with cryptogenic stroke. Without alternative explanations, it is frequently considered to be causative. A detailed stratification of these patients may improve the identification of incidental PFO. We investigated the PFO prevalence in 3497 transient ischemic attack and ischemic stroke patients aged 18 to 55 years in the prospective multicenter SIFAP1 study (Stroke in Young Fabry Patients 1) using the ASCO classification. Patients without an obvious cause for transient ischemic attack/stroke (ASCO 0) were divided into subgroups with and without vascular risk factors (ASCO 0+ and 0-). In addition, we looked for PFO-related magnetic resonance imaging lesion patterns. PFO was identified in 25% of patients. Twenty percent of patients with a definite or probable cause of transient ischemic attack/stroke (≥1 grade 1 or 2 ASCO criterion; n=1769) had a PFO compared with 29% of cryptogenic stroke patients (ASCO 0 and 3; n=1728; P<0,001); subdivision of cryptogenic strokes revealed a PFO in 24% of 978 ASCO 3 patients (n.s. versus ASCO 1 and 2) and a higher prevalence of 36% in 750 ASCO 0 cases (P<0.001 versus ASCO 3 and versus ASCO 1 and 2). PFO was more commonly observed in ASCO 0- (n=271) than in ASCO 0+ patients (n=479; 48 versus 29%; P<0.001). There was no PFO-associated magnetic resonance imaging lesion pattern. Cryptogenic stroke patients demonstrate a heterogeneous PFO prevalence. Even in case of less conclusive diseases like nonstenotic arteriosclerosis, patients should preferentially be considered to have a non-PFO-mediated stroke. URL: http://www.clinicaltrials.gov. Unique identifier: NCT00414583.-
dc.language.isoeng-
dc.subjectMRI-
dc.subjectarteriosclerosis-
dc.subjectIschaemic Stroke-
dc.subjectpatent foramen ovale-
dc.subjectRisk Factors-
dc.titlePatent Foramen Ovale and Cryptogenic Strokes in the Stroke in Young Fabry Patients Study.-
dc.typeJournal Article-
dc.identifier.journaltitleStroke-
dc.identifier.affiliationDepartment for Biostatistics and Clinical Epidemiologyand Center for Stroke Research, Charité-Universitätsmedizin Berlin, Germanyen
dc.identifier.affiliationDepartment of Neurology, Medical Campus Lake Constance, Klinikum Friedrichshafen, Germanyen
dc.identifier.affiliationDepartment of Neurology, University of Ulm, Ulm, Germanyen
dc.identifier.affiliationDepartment of Internal Medicine II, Katharinen Hospital, Unna, Germanyen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Neurology, Justus Liebig University Giessen, Germany-
dc.identifier.affiliationDepartment of Neurologyand Clinical Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria-
dc.identifier.affiliationDepartment of Neurology, University of Mannheim, Germany-
dc.identifier.affiliationDepartment of Neurology and Stroke Service, The Adelaide and Meath Hospital, incorporating the National Children's Hospital, Dublin, Ireland-
dc.identifier.affiliationDepartment of Clinical Neurosciences, Royal Free Campus, UCL Institute of Neurology, London, United Kingdom-
dc.identifier.affiliationAcademic Unit of Neurology, School of Medicine, Trinity College Dublin, Ireland-
dc.identifier.affiliationDepartment of Neurology, Helsinki University Central Hospital, Finland-
dc.identifier.affiliationInstitute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden-
dc.identifier.affiliationDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden-
dc.identifier.affiliationDepartment of Neurology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Germany-
dc.identifier.affiliationDepartment of Epidemiology and Biometrics, University of Tübingen, Germany-
dc.identifier.affiliationDepartment of Neurology, New York University School of Medicine-
dc.identifier.affiliationDepartment of Clinical Sciences, Section of Neurology, Lund University, Sweden-
dc.identifier.affiliationAlbrecht-Kossel-Institute for Neuroregeneration, University of Rostock, Germany-
dc.identifier.doi10.1161/STROKEAHA.116.013620-
dc.identifier.orcid0000-0002-6614-8417-
dc.identifier.pubmedid27899752-
dc.type.austinJournal Article-
dc.type.austinMulticenter Study-
dc.type.austinRandomized Controlled Trial-
dc.type.austinResearch Support, Non-U.S. Gov't-
local.name.researcherThijs, Vincent N
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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