Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/19119
Title: | Optimizing combination dabrafenib and trametinib therapy in BRAF mutation-positive advanced melanoma patients: Guidelines from Australian melanoma medical oncologists. | Austin Authors: | Atkinson, Victoria;Long, Georgina V;Menzies, Alexander M;McArthur, Grant;Carlino, Matteo S;Millward, Michael;Roberts-Thomson, Rachel;Brady, Benjamin;Kefford, Richard;Haydon, Andrew;Cebon, Jonathan S | Affiliation: | Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia Westmead Hospital and Macquarie University, Sydney, New South Wales, Australia The Alfred Hospital, Melbourne, Victoria, Australia Princess Alexandra Hospital, Greenslopes Private Hospital and University of Queensland, Brisbane, Queensland, Australia Melanoma Institute Australia, Royal North Shore and Mater Hospitals, The University of Sydney, Sydney, New South Wales, Australia Peter MacCallum Cancer Centre and Cabrini Health, Melbourne, Victoria, Australia Westmead Hospital, Sydney, New South Wales, Australia School of Medicine and Pharmacology, University of Western Australia, Australia and Sir Charles Gairdner Hospital, Perth, Western Australia, Australia Queen Elizabeth Hospital, Adelaide, South Australia |
Issue Date: | Dec-2016 | Publication information: | Asia-Pacific journal of clinical oncology 2016; 12 Suppl 7: 5-12 | Abstract: | BRAF mutations occur commonly in metastatic melanomas and inhibition of mutant BRAF and the downstream kinase MEK results in rapid tumor regression and prolonged survival in patients. Combined therapy with BRAF and MEK inhibition improves response rate, progression free survival and overall survival compared with single agent BRAF inhibition, and reduces the skin toxicity that is seen with BRAF inhibitor monotherapy. However, this combination is associated with an increase in other toxicities, particularly drug-related pyrexia, which affects approximately 50% of patients treated with dabrafenib and trametinib (CombiDT). We provide guidance on managing adverse events likely to arise during treatment with combination BRAF and MEK inhibition with CombiDT: pyrexia, skin conditions, fatigue; and discuss management of CombiDT during surgery and radiotherapy. By improving tolerability and in particular preventing unnecessary treatment cessations or reduction in drug exposure, best outcomes can be achieved for patients undergoing CombiDT therapy. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/19119 | DOI: | 10.1111/ajco.12656 | ORCID: | 0000-0002-3898-950X | Journal: | Asia-Pacific journal of clinical oncology | PubMed URL: | 27905182 | Type: | Journal Article | Subjects: | BRAF MEK dabrafenib Melanoma pyrexia trametinib |
Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.