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https://ahro.austin.org.au/austinjspui/handle/1/18964
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DC Field | Value | Language |
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dc.contributor.author | Barr, Elizabeth L M | - |
dc.contributor.author | Barzi, Federica | - |
dc.contributor.author | Hughes, Jaquelyne T | - |
dc.contributor.author | Jerums, George | - |
dc.contributor.author | O'Dea, Kerin | - |
dc.contributor.author | Brown, Alex Dh | - |
dc.contributor.author | Ekinci, Elif I | - |
dc.contributor.author | Jones, Graham R D | - |
dc.contributor.author | Lawton, Paul D | - |
dc.contributor.author | Sinha, Ashim | - |
dc.contributor.author | MacIsaac, Richard J | - |
dc.contributor.author | Cass, Alan | - |
dc.contributor.author | Maple-Brown, Louise J | - |
dc.date.accessioned | 2018-09-12T23:57:42Z | - |
dc.date.available | 2018-09-12T23:57:42Z | - |
dc.date.issued | 2018-07 | - |
dc.identifier.citation | Nephrology 2018; 23(7): 682-689 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/18964 | - |
dc.description.abstract | We assessed associations between cardiometabolic risk factors and estimated glomerular filtration rate (eGFR) decline according to baseline albuminuria to identify potential treatment targets in Indigenous Australians. The eGFR Follow-up Study is a longitudinal cohort of 520 Indigenous Australians. Linear regression was used to estimate associations between baseline cardiometabolic risk factors and annual Chronic Kidney Disease Epidemiology Collaboration eGFR change (mL/min per 1.73m2 /year), among those classified with baseline normoalbuminuria (urine albumin-to-creatinine ratio (uACR) <3 mg/mmol; n = 297), microalbuminuria (uACR 3-30 mg/mmol; n = 114) and macroalbuminuria (uACR ≥30 mg/mmol; n = 109). After a median of 3 years follow-up, progressive declines of the age- and sex-adjusted mean eGFR were observed across albuminuria categories (-2.0 [-2.6 to -1.4], -2.5 [-3.7 to -1.3] and -6.3 [-7.8 to -4.9] mL/min per 1.72m2 /year). Although a borderline association was observed between greater baseline haemoglobin A1c and eGFR decline in those with macroalbuminuria (P = 0.059), relationships were not significant in those with microalbuminuria (P = 0.187) or normoalbuminuria (P = 0.23). Greater baseline blood pressure, C-reactive protein, waist-to-hip ratio and lower high-density lipoprotein cholesterol showed non-significant trends with greater eGFR decline in the presence of albuminuria. Over a 3 year period, marked eGFR decline was observed with greater baseline albuminuria. Cardiometabolic risk factors were not strong predictors for eGFR decline in Indigenous Australians without albuminuria. Longer follow-up may elucidate the role of these predictors and other mechanisms in chronic kidney disease progression in this population. | - |
dc.language.iso | eng | - |
dc.subject | Indigenous | - |
dc.subject | albuminuria | - |
dc.subject | chronic kidney disease (CKD) | - |
dc.subject | diabetes mellitus | - |
dc.subject | haemoglobin A1c | - |
dc.subject | Risk Factors | - |
dc.title | Contribution of cardiometabolic risk factors to estimated glomerular filtration rate decline in Indigenous Australians with and without albuminuria - the eGFR Follow-up Study. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Nephrology | - |
dc.identifier.affiliation | Menzies School of Health Research, Darwin, North Territory, Australia | en |
dc.identifier.affiliation | Diabetes and Endocrinology, Cairns Base Hospital, Cairns, Australia | en |
dc.identifier.affiliation | Nutrition and Population Health, University of South Australia, Adelaide, South Australia, Australia | en |
dc.identifier.affiliation | Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Medicine, Royal Darwin Hospital, Darwin, North Territory, Australia | en |
dc.identifier.affiliation | Sansom Institute Health Research, University of South Australia, Adelaide, South Australia, Australia | en |
dc.identifier.affiliation | Department of Medicine, University of New South Wales, Sydney, Australia | en |
dc.identifier.affiliation | St Vincent's Hospital, Melbourne, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | SydPath, St Vincent's Hospital, Sydney, New South Wales, Australia | en |
dc.identifier.affiliation | South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia | en |
dc.identifier.affiliation | Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.doi | 10.1111/nep.13073 | - |
dc.identifier.orcid | 0000-0001-8058-6977 | en |
dc.identifier.orcid | 0000-0003-4284-1716 | - |
dc.identifier.orcid | 0000-0003-2372-395X | en |
dc.identifier.orcid | 0000-0002-1867-4156 | - |
dc.identifier.orcid | 0000-0003-2112-3918 | - |
dc.identifier.orcid | 0000-0002-5754-4821 | - |
dc.identifier.pubmedid | 28503768 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Ekinci, Elif I | |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Endocrinology | - |
crisitem.author.dept | Endocrinology | - |
Appears in Collections: | Journal articles |
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