Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18780
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGraudins, Linda V-
dc.contributor.authorTrubiano, Jason-
dc.contributor.authorZubrinich, Celia M-
dc.contributor.authorElliott, Ainslee S-
dc.contributor.authorAung, Ar Kar-
dc.date2018-07-27-
dc.date.accessioned2018-08-31T06:07:03Z-
dc.date.available2018-08-31T06:07:03Z-
dc.date.issued2018-
dc.identifier.citationPharmacoepidemiology and Drug Safety 2018; 27(9): 1029-1033en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18780-
dc.description.abstractOn background of increasing medication-related anaphylaxis rates in Australia, our aim was to determine epidemiology, outcomes, adverse drug reaction (ADR) reporting rates, and accuracy of coding in patients treated for nonantimicrobial medication-related anaphylaxis in our hospital network. From January 2010 to December 2015 patients treated in our hospital network for medication-related anaphylaxis were identified using International Classification of Diseases, 10th Edition diagnosis code T88.6. Cases were also extracted from the hospital ADR database. Medical records were reviewed to ensure consistent diagnosis and to extract clinical, documentation, and outcome data. Of 1110 patients coded as T88.6, 177 (15.9%) met the medication-related anaphylaxis definition. Eighty (40.8%) had anaphylaxis due to nonantimicrobial agents. Thirteen of these (16.3%) had a previous reaction to the same medication/group. In 51 (63.8%) patients, anaphylaxis occurred during inpatient stay, with 31 reactions occurring during surgery. Eighty-five medications were implicated, most commonly neuromuscular blocking agents (31, 36.5%) and nonsteroidal anti-inflammatory drugs. No trends were noted over the 6-year period, and there was no anaphylaxis-related mortality. Fifty-three (66.3%) patients were assessed in allergy clinics. One in 10 cases did not have the reaction documented in the discharge summary. Adverse drug reaction reports were received for 38 patients (47.5%). Although acute patient outcomes were excellent, gaps in practice were noted regarding ADR coding accuracy and reporting rates. One in 6 patients had a prior hypersensitivity reaction to a similar medication, so we recommend accurate documentation, ADR review with allergy follow-up, and patient held information to decrease re-exposure risk.en_US
dc.language.isoeng-
dc.subjectadverse drug reactionen_US
dc.subjectanaphylaxisen_US
dc.subjectdrug allergyen_US
dc.subjectmedication safetyen_US
dc.subjectpharmcoepidemiologyen_US
dc.titleMedication-related anaphylaxis treated in hospital: Agents implicated, patient outcomes, and management lessons.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitlePharmacoepidemiology and Drug Safetyen_US
dc.identifier.affiliationPharmacyen_US
dc.identifier.affiliationCentre for Antibiotic Allergy and Researchen_US
dc.identifier.affiliationDepartment of Allergy, Immunology and Respiratory Medicine, Alfred Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMonash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of General Medicine and Infectious Diseases, Alfred Health, and School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationAlfred Health, Melbourne, Victoria, Australiaen_US
dc.identifier.doi10.1002/pds.4587en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-6639-7210en_US
dc.identifier.orcid0000-0003-3317-945Xen_US
dc.identifier.pubmedid30051944-
dc.type.austinJournal Article-
local.name.researcherTrubiano, Jason-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

30
checked on Mar 29, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.