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Title: Characterisation and therapeutic manipulation of the gut microbiome in inflammatory bowel disease.
Austin Authors: Schulberg, J;De Cruz, P 
Affiliation: Department of Gastroenterology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
Issue Date: Mar-2016
Publication information: Internal Medicine Journal 2016; 46(3): 266-73
Abstract: Inflammatory bowel diseases are thought to develop as a result of dysregulation of the relationship that exists between the gut microbiota, host genetics and the immune system. The advent of culture-independent techniques has revolutionised the ability to characterise the role of the gut microbiota in health and disease based on the microbiota's genetic make-up. Inflammatory bowel diseases are characterised by dysbiosis which is an imbalance between pro- and anti-inflammatory bacteria and a reduction in bacterial diversity. Emerging data suggest that it is not only the presence of the gut microbiota but the functional activity of the microbiota that appears to play an important role in health and disease. Current strategies to manipulate therapeutically the gut microbiota using dietary modification, prebiotics, probiotics, antibiotics and faecal microbiota transplantation aim to restore the balance to a state of normobiosis. However, the ability of such strategies to correct dysbiosis and thereby achieve therapeutic benefit is yet to be fully characterised.
DOI: 10.1111/imj.13003
PubMed URL: 26968595
Type: Journal Article
Subjects: Crohn disease
faecal microbiota transplantation
ulcerative colitis
Appears in Collections:Journal articles

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