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dc.contributor.authorTrubiano, Jason A-
dc.contributor.authorCairns, Kelly A-
dc.contributor.authorEvans, Jacqui A-
dc.contributor.authorDing, Amally-
dc.contributor.authorNguyen, Tuan-
dc.contributor.authorDooley, Michael J-
dc.contributor.authorCheng, Allen C-
dc.identifier.citationBMC infectious diseases 2015; 15: 572-
dc.description.abstractThe prevalence and impact of antimicrobial "allergy" labels and Adverse Drug Reactions (ADRs) on antibiotic usage and antimicrobial stewardship initiatives is ill defined. We sought to examine the rate of antimicrobial "allergy labels" at our tertiary referral centre and impacts on antimicrobial usage and appropriateness. Two inpatient antimicrobial prevalence surveys were conducted over a 1-week period in November 2013 and 2014 as part of the prospective National Antimicrobial Prescribing Survey (NAPS). Post survey, patients recorded in the NAPS database were assigned to two groups based upon recorded antimicrobial "allergy label" and ADR: (i) Antimicrobial Allergy/ADR (AA) or (ii) No Antimicrobial Allergy/ADR (NAA). Antimicrobial usage and antimicrobial appropriateness were compared between AA and NAA groups. From 509 identified patients the prevalence of an antimicrobial allergy or ADR was 25 %. The prevalence of "allergy labels"/ADR was 10 % (51/509) for penicillin V/G, 5 % (24/509) cephalosporins, 4 % (22/509) trimethroprim-sulfamethoxazole and 3 % (17/509) aminopenicillins. One thousand and seventy antimicrobials were prescribed during the study periods, the median antimicrobial duration was longer in the AA versus NAA group (6 days vs. 4 days; p = 0.018), and proportion of inappropriate antimicrobial prescribing higher in the AA group compared with NAA (29 %; 35/120 vs. 23 %; 86/367, p = 0.22). Oral antimicrobial administration was higher in the NAA than AA group (60 %; 177/297 vs. 46 %; 356/793, p = 0.0001). The proportion of patients that received a β-lactam was lower in the AA versus NAA group (60 % vs. 79 %, p = 0.0001). In an Australian tertiary referral centre an antimicrobial "allergy" or ADR label was found to significantly impacted on rate of oral antimicrobial administration, beta-lactam usage, antimicrobial duration and antimicrobial appropriateness.-
dc.titleThe prevalence and impact of antimicrobial allergies and adverse drug reactions at an Australian tertiary centre.-
dc.typeJournal Article-
dc.identifier.journaltitleBMC infectious diseases-
dc.identifier.affiliationInfection Prevention and Healthcare Epidemiology Unit, Alfred Health and Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationPharmacy Department, Alfred Hospital and Centre for Medication Use and Safety, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Infectious Diseases, Alfred Health and Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Pharmacy, Alfred Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMonash University, Melbourne, Victoria, Australiaen
dc.type.austinJournal Article-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Diseases- (University of Melbourne)- for Antibiotic Allergy and Research-
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