Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18478
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dc.contributor.authorWoodhouse, Lisa J-
dc.contributor.authorScutt, Polly-
dc.contributor.authorHamdy, Shaheen-
dc.contributor.authorSmithard, David G-
dc.contributor.authorCohen, David L-
dc.contributor.authorRoffe, Christine-
dc.contributor.authorBereczki, Daniel-
dc.contributor.authorBerge, Eivind-
dc.contributor.authorBladin, Christopher F-
dc.contributor.authorCaso, Valeria-
dc.contributor.authorChristensen, Hanne K-
dc.contributor.authorCollins, Rónán-
dc.contributor.authorCzlonkowska, Anna-
dc.contributor.authorde Silva, Asita-
dc.contributor.authorEtribi, Anwar-
dc.contributor.authorLaska, Ann-Charlotte-
dc.contributor.authorNtaios, George-
dc.contributor.authorOzturk, Serefnur-
dc.contributor.authorPhillips, Stephen J-
dc.contributor.authorPrasad, Kameshwar-
dc.contributor.authorSzatmari, Szabolcs-
dc.contributor.authorSprigg, Nikola-
dc.contributor.authorBath, Philip M-
dc.date2017-08-02-
dc.date.accessioned2018-08-30T06:06:19Z-
dc.date.available2018-08-30T06:06:19Z-
dc.date.issued2018-04-
dc.identifier.citationTranslational stroke research 2018; 9(2): 120-129-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18478-
dc.description.abstractPost-stroke dysphagia is common, associated with poor outcome and often requires non-oral feeding/fluids. The relationship between route of feeding and outcome, as well as treatment with glyceryl trinitrate (GTN), was studied prospectively. The Efficacy of Nitric Oxide in Stroke (ENOS) trial assessed transdermal GTN (5 mg versus none for 7 days) in 4011 patients with acute stroke and high blood pressure. Feeding route (oral = normal or soft diet; non-oral = nasogastric tube, percutaneous endoscopic gastrostomy tube, parenteral fluids, no fluids) was assessed at baseline and day 7. The primary outcome was the modified Rankin Scale (mRS) measured at day 90. At baseline, 1331 (33.2%) patients had non-oral feeding, were older, had more severe stroke and more were female, than 2680 (66.8%) patients with oral feeding. By day 7, 756 patients had improved from non-oral to oral feeding, and 119 had deteriorated. Non-oral feeding at baseline was associated with more impairment at day 7 (Scandinavian Stroke Scale 29.0 versus 43.7; 2p < 0.001), and worse mRS (4.0 versus 2.7; 2p < 0.001) and death (23.6 versus 6.8%; 2p = 0.014) at day 90. Although GTN did not modify route of feeding overall, randomisation ≤6 h of stroke was associated with a move to more oral feeding at day 7 (odds ratio = 0.61, 95% confidence intervals 0.38, 0.98; 2p = 0.040). As a proxy for dysphagia, non-oral feeding is present in 33% of patients with acute stroke and associated with more impairment, dependency and death. GTN moved feeding route towards oral intake if given very early after stroke. Clinical Trial Registration Clinical Trial Registration-URL: http://www.controlled-trials.com . Unique identifier: ISRCTN99414122.-
dc.language.isoeng-
dc.subjectNitric Oxideen
dc.subjectVasodilator Agentsen
dc.subjectDysphagia-
dc.subjectDeglutition Disordersen
dc.subjectNitroglycerinen
dc.subjectGlyceryl trinitrate-
dc.subjectOutcome-
dc.subjectRandomised controlled trial-
dc.subjectStroke-
dc.titleRoute of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial.-
dc.typeJournal Article-
dc.identifier.journaltitleTranslational stroke research-
dc.identifier.affiliationStroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, City Hospital Campus, Hucknall Road, Nottingham, NG5 1PB, UK-
dc.identifier.affiliationStroke, Nottingham University Hospitals NHS Trust, Nottingham, UKen
dc.identifier.affiliationCentre for Gastrointestinal Sciences, University of Manchester, Salford, UK-
dc.identifier.affiliationElderly Medicine, Princess Royal University Hospital, Orpington, UK-
dc.identifier.affiliationInstitute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, UK-
dc.identifier.affiliationNeurology, Semmelweis University, Balassu, Budapest, Hungary-
dc.identifier.affiliationOslo University Hospital, Oslo, Norway-
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationStroke Unit, Ospedale Santa Maria della Misericordia di Perugia, Perugia, Italy-
dc.identifier.affiliationNeurology, Bispebjerg Hospital & University of Copenhagen, Copenhagen, Denmark-
dc.identifier.affiliationStroke Service, Tallaght Hospital, Tallaght Dublin, Ireland-
dc.identifier.affiliationNeurology 2, Institute of Psychiatry and Neurology, Warsaw, Poland-
dc.identifier.affiliationClinical Trials Unit, University of Kelaniya, Ragama, Sri Lanka-
dc.identifier.affiliationNeurology, Ainshams University, Cairo, Egypt-
dc.identifier.affiliationClinical Sciences, Karolinska Institute, Stockholm, Sweden-
dc.identifier.affiliationMedicine, University of Thessaly, Larissa, Greece-
dc.identifier.affiliationNeurology, Selcuk University, Konya, Turkey-
dc.identifier.affiliationDivision of Neurology, Halifax Infirmary, Halifax, Canada-
dc.identifier.affiliationNeurology, All India Institute of Medical Sciences, New Delhi, India-
dc.identifier.affiliationNeurology, Clinical County Emergency Hospital, Targu Mures, Romania-
dc.identifier.doi10.1007/s12975-017-0548-0-
dc.identifier.pubmedid28770403-
dc.type.austinJournal Article-
dc.type.austinResearch Support, Non-U.S. Gov't-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
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