Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18389
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dc.contributor.authorPedrini, Steve-
dc.contributor.authorGupta, Veer B-
dc.contributor.authorHone, Eugene-
dc.contributor.authorDoecke, James-
dc.contributor.authorO'Bryant, Sid-
dc.contributor.authorJames, Ian-
dc.contributor.authorBush, Ashley I-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorMartins, Ralph N-
dc.date2017-10-25-
dc.date.accessioned2018-08-30T05:58:46Z-
dc.date.available2018-08-30T05:58:46Z-
dc.date.issued2017-10-25-
dc.identifier.citationScientific Reports 2017; 7(1): 14057en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18389-
dc.description.abstractAlzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ε4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ε4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD and/or early stage AD for which current therapies may be more beneficial.en
dc.language.isoeng-
dc.titleA blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort.en
dc.typeJournal Articleen
dc.identifier.journaltitleScientific Reportsen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old age, St. George's Hospital, The University of Melbourne, Parkville, VIC 3052, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, VIC 3052, Australiaen
dc.identifier.affiliationSchool of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA 6009, Australiaen
dc.identifier.affiliationDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australiaen
dc.identifier.affiliationSchool of Medical Sciences, Edith Cowan University, Joondalup, WA 6027, Australiaen
dc.identifier.affiliationCo-operative Research Centre for Mental Health, Carlton, VIC 3053, Australiaen
dc.identifier.affiliationCSIRO Digital Productivity Flagship, Brisbane, QLD 4029, Australiaen
dc.identifier.affiliationUniversity of North Texas Health Science Center, Fort Worth, 76107, Texas, USAen
dc.identifier.affiliationInstitute for Immunology & Infectious Diseases, Murdoch University, Murdoch, WA 6150, Australiaen
dc.identifier.affiliationThe Florey Institute, The University of Melbourne, Parkville, VIC 3052, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1038/s41598-017-14020-9en
dc.type.contentTexten
dc.identifier.orcid0000-0003-2863-0293en
dc.identifier.orcid0000-0001-8259-9069en
dc.identifier.orcid0000-0003-3910-2453en
dc.identifier.pubmedid29070909-
dc.type.austinJournal Article-
local.name.researcherMasters, Colin L
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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