Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18265
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dc.contributor.authorLee, Ting Ting-
dc.contributor.authorSkafidas, Efstratios-
dc.contributor.authorDottori, Mirella-
dc.contributor.authorZantomio, Daniela-
dc.contributor.authorPantelis, Christos-
dc.contributor.authorEverall, Ian-
dc.contributor.authorChana, Gursharan-
dc.date2017-12-08-
dc.date.accessioned2018-08-27T05:25:55Z-
dc.date.available2018-08-27T05:25:55Z-
dc.date.issued2017-12-08-
dc.identifier.citationMolecular autism 2017; 8: 64-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/18265-
dc.description.abstractWhile evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes has not been conducted. Such an investigation is further warranted by an increasing role for neuroinflammation in autism pathogenesis, with astrocytes being key players in this process. We present the first study of astrocyte density and morphology within the white matter of the dorsolateral prefrontal cortex (DLPFC) in individuals with autism. DLPFC formalin-fixed sections containing white matter from individuals with autism (n = 8, age = 4-51 years) and age-matched controls (n = 7, age = 4-46 years) were immunostained for glial fibrillary acidic protein (GFAP). Density of astrocytes and other glia were estimated via the optical fractionator, astrocyte somal size estimated via the nucleator, and astrocyte process length via the spaceballs probe. We found no evidence for alteration in astrocyte density within DLPFC white matter of individuals with autism versus controls, together with no differences in astrocyte somal size and process length. Our results suggest that astrocyte abnormalities within the white matter in the DLPFC in autism may be less pronounced than previously thought. However, astrocytic dysregulation may still exist in autism, even in the absence of gross morphological changes. Our lack of evidence for astrocyte abnormalities could have been confounded to an extent by having a small sample size and wide age range, with pathological features potentially restricted to early stages of autism. Nonetheless, future investigations would benefit from assessing functional markers of astrocytes in light of the underlying pathophysiology of autism.-
dc.language.isoeng-
dc.subjectAstrocytes-
dc.subjectAutism-
dc.subjectCell density-
dc.subjectDorsolateral prefrontal cortex (DLPFC)-
dc.subjectGlia-
dc.subjectWhite matter-
dc.titleNo preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism.-
dc.typeJournal Article-
dc.identifier.journaltitleMolecular autism-
dc.identifier.affiliationCentre for Neural Engineering, The University of Melbourne, Parkville, Australia-
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia-
dc.identifier.affiliationDepartment of Biomedical Engineering, The University of Melbourne, Parkville, Australia-
dc.identifier.affiliationIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia-
dc.identifier.affiliationDepartment of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationMelbourne Neuropsychiatry Centre, The University of Melbourne & Melbourne Health, Parkville, Australia-
dc.identifier.affiliationDepartment of Psychiatry, The University of Melbourne, Parkville, Australia-
dc.identifier.affiliationThe Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK-
dc.identifier.affiliationDepartment of Medicine, The University of Melbourne, Parkville, Australia-
dc.identifier.doi10.1186/s13229-017-0181-5-
dc.identifier.orcid0000-0002-3488-0267-
dc.identifier.pubmedid29234492-
dc.type.austinJournal Article-
dc.type.austinResearch Support, Non-U.S. Gov't-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptClinical Haematology-
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