Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18256
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dc.contributor.authorCheuk, Ka Yee-
dc.contributor.authorWang, Xiao-Fang-
dc.contributor.authorWang, Ji-
dc.contributor.authorZhang, Zhendong-
dc.contributor.authorYu, Fiona Wai Ping-
dc.contributor.authorTam, Elisa Man Shan-
dc.contributor.authorHung, Vivian Wing Yin-
dc.contributor.authorLee, Wayne Yuk Wai-
dc.contributor.authorGhasem-Zadeh, Ali-
dc.contributor.authorZebaze, Roger M D-
dc.contributor.authorZhu, Tracy Y-
dc.contributor.authorGuo, X Edward-
dc.contributor.authorCheng, Jack Chun Yiu-
dc.contributor.authorLam, Tsz Ping-
dc.contributor.authorSeeman, Ego-
dc.date2018-07-12-
dc.date.accessioned2018-08-27T05:25:29Z-
dc.date.available2018-08-27T05:25:29Z-
dc.date.issued2018-07-12-
dc.identifier.citationournal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 2018; 33(11): 1948-1955en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18256-
dc.description.abstractDistal forearm fractures during growth are more common in males than females. Because metaphyseal cortical bone is formed by coalescence of trabeculae emerging from the periphery of the growth plate, we hypothesized that the later onset of puberty in males produces a longer delay in trabecular bone formation and coalescence, which leaves a transient phase of high cortical porosity, low matrix mineral density, and high trabecular density relative to females. We quantified the nondominant distal radial microstructure using high-resolution peripheral quantitative computed tomography in 214 healthy Chinese boys and 219 Chinese girls aged between 7 and 17 years living in Hong Kong. Measurements of 110 slices (9.02 mm) were acquired 5 mm proximal to the growth plate of the nondominant distal radius. Porosity was measured using StrAx1.0 (Straxcorp, Melbourne, VIC, Australia) and trabecular plate and rod structure were measured using individual trabecula segmentation (ITS). Mechanical properties were estimated using finite element analysis (FEA). Results were adjusted for age, total bone cross-sectional area (CSA), dietary calcium intake, and physical activity. In boys, total bone CSA was 17.2% to 22.9% larger throughout puberty, cortical/total bone CSA was 5.1% smaller in Tanner stage 2 only, cortical porosity was 9.4% to 17.5% higher, and matrix mineral density was 1.0% to 2.5% lower in Tanner stage 2 to 5, than girls. Boys had higher trabecular rod BV/TV in Tanner stage 3 and 4, but higher trabecular plate BV/TV and plate to rod ratio in Tanner stage 5, than girls. Boys had 17.0% lower apparent modulus than girls in Tanner stage 2. A transient phase of higher porosity due to dissociation between bone mineral accrual and linear growth may contribute to higher distal radial bone fragility in Chinese boys compared to girls. © 2018 American Society for Bone and Mineral Research.en_US
dc.language.isoeng-
dc.subjectADOLESCENTen_US
dc.subjectBONEen_US
dc.subjectCHINESEen_US
dc.subjectMICROSTRUCTUREen_US
dc.subjectPUBERTYen_US
dc.subjectSEXen_US
dc.titleSexual Dimorphism in Cortical and Trabecular Bone Microstructure Appears During Puberty in Chinese Children.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Researchen_US
dc.identifier.affiliationDepartment of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, Chinaen_US
dc.identifier.affiliationSH Ho Scoliosis Research Laboratory, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Chinaen_US
dc.identifier.affiliationJoint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University, The Chinese University of Hong Kong, Hong Kong, Chinaen_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USAen_US
dc.identifier.affiliationBone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, Chinaen_US
dc.identifier.affiliationMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australiaen_US
dc.identifier.doi10.1002/jbmr.3551en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-9692-048Xen_US
dc.identifier.pubmedid30001459-
dc.type.austinJournal Article-
local.name.researcherGhasem-Zadeh, Ali
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
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