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Title: Effect of 0.9% Saline or Plasma-Lyte 148 as Crystalloid Fluid Therapy in the Intensive Care Unit on Blood Product Use and Postoperative Bleeding After Cardiac Surgery.
Austin Authors: Reddy, Sumeet K;Bailey, Michael J;Beasley, Richard W;Bellomo, Rinaldo ;Mackle, Diane M;Psirides, Alex J;Young, Paul J
Affiliation: Medical Research Institute of New Zealand, Wellington, New Zealand
Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia
Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australia
Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand
Issue Date: Oct-2017 2017-04-15
Publication information: Journal of Cardiothoracic and Vascular Anesthesia 2017; 31(5): 1630-1638
Abstract: To evaluate the effect of Plasma-Lyte 148 (PL-148) compared with 0.9% saline (saline) on blood product use and postoperative bleeding in patients admitted to the intensive care unit (ICU) following cardiac surgery. A post hoc subgroup analysis conducted within a multicenter, double-blind, cluster-randomized, double-crossover study (study 1) and a prospective, single-center nested-cohort study (study 2). Tertiary-care hospitals. Adults admitted to the ICU after cardiac surgery requiring crystalloid fluid therapy as part of the 0.9% saline vs. PL-148 for ICU fluid therapy (SPLIT) trial. Blinded saline or PL-148 for 4 alternating 7-week blocks. 954 patients were included in study 1; 475 patients received PL-148, and 479 received saline. 128 of 475 patients (26.9%) in the PL-148 group received blood or a blood product compared with 94 of 479 patients (19.6%) in the saline group (OR [95% confidence interval], 1.51 [1.11-2.05]; p = 0.008). In study 2, 131 patients were allocated to PL-148 and 120 patients were allocated to saline. There were no differences between groups in chest drain output from the time of arrival in the ICU until 12 hours postoperatively (geometric mean, 566 mL for the PL-148 group v 547 mL in the saline group; p = 0.60). The findings did not support the hypothesis that using PL-148 for fluid therapy in ICU following cardiac surgery reduces transfusion requirements compared to saline. The significantly increased proportion of patients receiving blood or blood product with allocation to PL-148 compared to saline was unexpected and requires verification through further research.
DOI: 10.1053/j.jvca.2017.04.023
ORCID: 0000-0002-1650-8939
PubMed URL: 28774642
Type: Journal Article
Subjects: 0.9% saline
Plasma-Lyte 148
cardiac surgery
critical care
fluid resuscitation
Appears in Collections:Journal articles

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