Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18036
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dc.contributor.authorAljondi, Rowa-
dc.contributor.authorSzoeke, Cassandra-
dc.contributor.authorSteward, Chris-
dc.contributor.authorYates, Paul A-
dc.contributor.authorDesmond, Patricia-
dc.date2018-05-09-
dc.date.accessioned2018-07-10T06:23:15Z-
dc.date.available2018-07-10T06:23:15Z-
dc.date.issued2019-04-
dc.identifier.citationBrain imaging and behavior 2019; 13(2): 554-563-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/18036-
dc.description.abstractBrain atrophy can occur several decades prior to onset of cognitive impairments. However, few longitudinal studies have examined the relationship between brain volume changes and cognition over a long follow-up period in healthy elderly women. In the present study we investigate the relationship between whole brain and hippocampal atrophy rates and longitudinal changes in cognition, including verbal episodic memory and executive function, in older women. We also examine whether baseline brain volume predicts subsequent changes in cognitive performance over a 10-year period. A total of 60 individuals from the population-based Women's Healthy Ageing Project with a mean age at baseline of 59 years underwent 3T MRI. Of these, 40 women completed follow-up cognitive assessments, 23 of whom had follow-up MRI scans. Linear regression analysis was used to examine the relationship between brain atrophy and changes in verbal episodic memory and executive function over a 10-year period. The results show that baseline measurements of frontal and temporal grey matter volumes predict changes in verbal episodic memory performance, whereas hippocampal volume at baseline is associated with changes in executive function performance over a 10-year period of follow-ups. In addition, higher whole brain and hippocampal atrophy rates are correlated with a decline in verbal episodic memory. These findings indicate that in addition to atrophy rate, smaller regional grey matter volumes even 10 years prior is associated with increased rates of cognitive decline. This study suggests useful neuroimaging biomarkers for the prediction of cognitive decline in healthy elderly women.-
dc.language.isoeng-
dc.subjectBrain atrophy-
dc.subjectElderly women-
dc.subjectEpisodic memory-
dc.subjectExecutive function-
dc.subjectHippocampal atrophy-
dc.subjectNormal aging-
dc.titleA decade of changes in brain volume and cognition.-
dc.typeJournal Article-
dc.identifier.journaltitleBrain imaging and behavior-
dc.identifier.affiliationDepartment of Medicine (Royal Melbourne Hospital), The University of Melbourne, Parkville, Victoria, 3052, Australia-
dc.identifier.affiliationInstitute for Health and Ageing, Australian Catholic University, Melbourne, Victoria, 3000, Australia-
dc.identifier.affiliationDepartment of Aged Care Services, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Radiology, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia-
dc.identifier.doi10.1007/s11682-018-9887-z-
dc.identifier.pubmedid29744801-
dc.type.austinJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptAged Care-
crisitem.author.deptGeriatric Medicine-
Appears in Collections:Journal articles
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