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dc.contributor.authorLim, Hui Y-
dc.contributor.authorNg, Cheryl-
dc.contributor.authorRigano, Joseph-
dc.contributor.authorTacey, Mark A-
dc.contributor.authorDonnan, Geoffrey A-
dc.contributor.authorNandurkar, Harshal-
dc.contributor.authorHo, Prahlad-
dc.identifier.citationBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2018; 29(3): 300-306en
dc.description.abstractMyeloproliferative neoplasms (MPN) are independent risks for thrombotic events. Routine laboratory tests are inadequate to evaluate the underlying procoagulant state. Global coagulation assays such as thromboelastography, thrombin and fibrin generation may provide better assessment of coagulation activation and thereby of thrombosis risk. Participants with MPN were recruited. Thromboelastography was performed on citrated whole blood while thrombin generation using calibrated automated thrombogram, fibrin generation using overall haemostatic potential assays and P-selectin were quantified on platelet-poor plasma. Thirty-eight MPN patients (median age: 65 years) were recruited. There were 26 patients with essential thrombocythemia (68.4%), eight polycythemia vera (20.5%), three primary myelofibrosis and one MPN, unclassifiable. Compared with normal controls, there was no difference in maximum amplitude although lysis time (LY30) was significantly higher (2.9 vs. 0.6%, adjusted P < 0.01) using thromboelastography. Calibrated automated thrombogram showed higher thrombin peak (260.8 vs. 222.6 nmol/l; P < 0.01) and velocity index (91.1 vs. 65.0 nmol/l/min; P < 0.01) with comparable endogenous thrombin potential. Fibrin generation parameters were significantly reduced with preserved overall fibrinolytic potential, whereas P-selectin was markedly increased (108.9 vs. 49.3 ng/ml, P < 0.01). This study demonstrated unique differences between MPN population and normal controls using a combination of global coagulation assays. The presence of high lysis time (LY30) and reduced fibrin generation in MPN patients were contradictory to the prothrombotic nature and may represent a compensatory effort to achieve equilibrium within the Virchow's triad. Both markers may be important prognostic indicators of thrombosis in MPN and further prospective studies to confirm these findings are proposed.en
dc.titleAn evaluation of global coagulation assays in myeloproliferative neoplasm.en
dc.typeJournal Articleen
dc.identifier.journaltitleBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosisen
dc.identifier.affiliationDepartment of Haematology, Northern Hospitalen
dc.identifier.affiliationAustin Pathology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationAustralian Centre for Blood Diseases, Monash Universityen
dc.type.austinJournal Article-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en- Oncology- Newton-John Cancer Wellness and Research Centre- Florey Institute of Neuroscience and Mental Health-
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