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dc.contributor.authorGoodin, Peter-
dc.contributor.authorLamp, Gemma-
dc.contributor.authorVidyasagar, Rishma-
dc.contributor.authorMcArdle, David-
dc.contributor.authorSeitz, Rüdiger J-
dc.contributor.authorCarey, Leeanne M-
dc.identifier.citationNeuroImage. Clinical 2018; 18: 342-355-
dc.description.abstractOne in two survivors experience impairment in touch sensation after stroke. The nature of this impairment is likely associated with changes associated with the functional somatosensory network of the brain; however few studies have examined this. In particular, the impact of lesioned hemisphere has not been investigated. We examined resting state functional connectivity in 28 stroke survivors, 14 with left hemisphere and 14 with right hemisphere lesion, and 14 healthy controls. Contra-lesional hands showed significantly decreased touch discrimination. Whole brain functional connectivity (FC) data was extracted from four seed regions, i.e. primary (S1) and secondary (S2) somatosensory cortices in both hemispheres. Whole brain FC maps and Laterality Indices (LI) were calculated for subgroups. Inter-hemispheric FC was greater in healthy controls compared to the combined stroke cohort from the left S1 seed and bilateral S2 seeds. The left lesion subgroup showed decreased FC, relative to controls, from left ipsi-lesional S1 to contra-lesional S1 and to distributed temporal, occipital and parietal regions. In comparison, the right lesion group showed decreased connectivity from contra-lesional left S1 and bilateral S2 to ipsi-lesional parietal operculum (S2), and to occipital and temporal regions. The right lesion group also showed increased intra-hemispheric FC from ipsi-lesional right S1 to inferior parietal regions compared to controls. In comparison to the left lesion group, those with right lesion showed greater intra-hemispheric connectivity from left S1 to left parietal and occipital regions and from right S1 to right angular and parietal regions. Laterality Indices were significantly greater for stroke subgroups relative to matched controls for contra-lesional S1 (left lesion group) and contra-lesional S2 (both groups). We provide evidence of altered functional connectivity within the somatosensory network, across both hemispheres, and to other networks in stroke survivors with impaired touch sensation. Hemisphere of lesion was associated with different patterns of altered functional connectivity within the somatosensory network and with related function was associated with different patterns of altered functional connectivity within the somatosensory network and with related functional networks.-
dc.subjectBrain imaging-
dc.subjectFunctional connectivity-
dc.subjectResting state fMRI-
dc.titleAltered functional connectivity differs in stroke survivors with impaired touch sensation following left and right hemisphere lesions.-
dc.typeJournal Article-
dc.identifier.journaltitleNeuroImage. Clinical-
dc.identifier.affiliationNeurorehabilitation and Recovery, Stroke Division, Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationOccupational Therapy, Department of Community and Clinical Allied Health, School of Allied Health, College of Science, Health and Engineering, La Trobe University, Bundoora, Victoria, Australia-
dc.identifier.affiliationDepartment of Neurosurgery, Royal Hobart Hospital, Tasmania, Australia-
dc.identifier.affiliationDepartment of Neurology, Centre for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany-
dc.type.austinJournal Article-, Leeanne M
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Florey Institute of Neuroscience and Mental Health-
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