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dc.contributor.authorStark, Zornitza-
dc.contributor.authorWallaca, Jane-
dc.contributor.authorGillam, Lynn-
dc.contributor.authorBurgess, Matthew-
dc.contributor.authorDelatycki, Martin B-
dc.identifier.citationJournal of Medical Ethics 2016; 42(10): 640-642en_US
dc.description.abstractPredictive genetic testing for a neurodegenerative condition in one individual in a family may have implications for other family members, in that it can reveal their genetic status. Herein a complex clinical case is explored where the testing wish of one family member was in direct conflict to that of another. The son of a person at 50% risk of an autosomal dominant neurodegenerative condition requested testing to reveal his genetic status. The main reason for the request was if he had the familial mutation, he and his partner planned to utilise preimplantation genetic diagnosis to prevent his offspring having the condition. His at-risk parent was clear that if they found out they had the mutation, they would commit suicide. We assess the potential benefits and harms from acceding to or denying such a request and present an approach to balancing competing rights of individuals within families at risk of late-onset genetic conditions, where family members have irreconcilable differences with respect to predictive testing. We argue that while it may not be possible to completely avoid harm in these situations, it is important to consider the magnitude of risks, and make every effort to limit the potential for adverse outcomes.en_US
dc.subjectGenetic Counselling/Prenatal Diagnosisen_US
dc.subjectGenetic Screening/Testingen_US
dc.subjectDecision Makingen_US
dc.subjectGenetic Counselingen_US
dc.subjectGenetic Predisposition to Disease/psychologyen_US
dc.subjectPreimplantation Diagnosisen_US
dc.titlePredictive genetic testing for neurodegenerative conditions: how should conflicting interests within families be managed?en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Medical Ethicsen_US
dc.identifier.affiliationMurdoch Childrens Research Institute, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationVictorian Clinical Genetics Services, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationUniversity of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Clinical Genetics, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Genetics-
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