Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17702
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dc.contributor.authorLibianto, Renata-
dc.contributor.authorBatu, Duygu-
dc.contributor.authorMacIsaac, Richard J-
dc.contributor.authorCooper, Mark E-
dc.contributor.authorEkinci, Elif I-
dc.date2018-01-31-
dc.date.accessioned2018-05-08T23:56:56Z-
dc.date.available2018-05-08T23:56:56Z-
dc.date.issued2018-05-
dc.identifier.citationThe Canadian Journal of Cardiology 2018; 34(5): 585-594en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17702-
dc.description.abstractHypertension is highly prevalent among people with diabetes, and the presence of diabetes among those with hypertension portends an increase in cardiovascular risk. In this review we aim to explore the pathophysiological links between diabetes and hypertension. Renal sodium handling differs in diabetes because there is an upregulation of sodium transporters in the kidneys. The renin-angiotensin-aldosterone system may be upregulated in diabetes, leading to hypertension through a direct effect mediated by angiotensin II, as well as indirectly through upregulation of sympathetic activity. Renin-angiotensin-aldosterone system blockade is a mainstay therapy for hypertension, and evidence suggests that it might also reduce the incidence of diabetes. People with diabetes frequently have autonomic dysfunction, which could contribute to hypertension through increased sympathetic tone and through stimulation of renin production in the juxtaglomerular apparatus. Furthermore, people with diabetes also frequently show an abnormality in their circadian blood pressure pattern. Another important link between hypertension and diabetes is the development as well as progression of diabetic kidney disease, the pathophysiology of which is mediated through several pathways including endothelial dysfunction and advanced glycation end products. Finally, obesity and the metabolic syndrome, through their effects on various hormones and inflammation, might also contribute to the pathogenesis of hypertension and diabetes.en_US
dc.language.isoeng-
dc.titlePathophysiological Links Between Diabetes and Blood Pressure.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleThe Canadian Journal of Cardiologyen_US
dc.identifier.affiliationDepartment of Medicine, The University of Melbourne, Melbourne, Australiaen_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.affiliationDepartment of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, Monash University, Melbourne, Australiaen_US
dc.identifier.doi10.1016/j.cjca.2018.01.010en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-2372-395Xen_US
dc.identifier.pubmedid29731021-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherBatu, Duygu
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
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