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dc.contributor.authorDevinsky, Orrin-
dc.contributor.authorVezzani, Annamaria-
dc.contributor.authorO'Brien, Terence J-
dc.contributor.authorJette, Nathalie-
dc.contributor.authorScheffer, Ingrid E-
dc.contributor.authorde Curtis, Marco-
dc.contributor.authorPerucca, Piero-
dc.identifier.citationNature reviews. Disease primers 2018; 4: 18024en
dc.description.abstractEpilepsy affects all age groups and is one of the most common and most disabling neurological disorders. The accurate diagnosis of seizures is essential as some patients will be misdiagnosed with epilepsy, whereas others will receive an incorrect diagnosis. Indeed, errors in diagnosis are common, and many patients fail to receive the correct treatment, which often has severe consequences. Although many patients have seizure control using a single medication, others require multiple medications, resective surgery, neuromodulation devices or dietary therapies. In addition, one-third of patients will continue to have uncontrolled seizures. Epilepsy can substantially impair quality of life owing to seizures, comorbid mood and psychiatric disorders, cognitive deficits and adverse effects of medications. In addition, seizures can be fatal owing to direct effects on autonomic and arousal functions or owing to indirect effects such as drowning and other accidents. Deciphering the pathophysiology of epilepsy has advanced the understanding of the cellular and molecular events initiated by pathogenetic insults that transform normal circuits into epileptic circuits (epileptogenesis) and the mechanisms that generate seizures (ictogenesis). The discovery of >500 genes associated with epilepsy has led to new animal models, more precise diagnoses and, in some cases, targeted therapies.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature reviews. Disease primersen
dc.identifier.affiliationDepartments of Neurology, Neuroscience, Neurosurgery and Psychiatry, NYU School of Medicine, New York, NY, USAen
dc.identifier.affiliationLaboratory of Experimental Neurology, Department of Neuroscience, IRCCS 'Mario Negri' Institute for Pharmacological Research, Milan, Italyen
dc.identifier.affiliationDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Neurology, Alfred Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartments of Neurology and Medicine, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Neurology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USAen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Paediatrics, The University of Melbourne, and Department of Neurology, The Royal Children's Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationEpilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italyen
dc.type.austinJournal Article-
item.openairetypeJournal Article-
item.fulltextNo Fulltext- Research Centre- Epilepsy Program-
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