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https://ahro.austin.org.au/austinjspui/handle/1/17546
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DC Field | Value | Language |
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dc.contributor.author | Phan, Hoang T | - |
dc.contributor.author | Blizzard, Christopher L | - |
dc.contributor.author | Reeves, Mathew J | - |
dc.contributor.author | Thrift, Amanda G | - |
dc.contributor.author | Cadilhac, Dominique A | - |
dc.contributor.author | Sturm, Jonathan | - |
dc.contributor.author | Heeley, Emma | - |
dc.contributor.author | Otahal, Petr | - |
dc.contributor.author | Vemmos, Konstantinos | - |
dc.contributor.author | Anderson, Craig | - |
dc.contributor.author | Parmar, Priya | - |
dc.contributor.author | Krishnamurthi, Rita | - |
dc.contributor.author | Barker-Collo, Suzanne | - |
dc.contributor.author | Feigin, Valery | - |
dc.contributor.author | Bejot, Yannick | - |
dc.contributor.author | Cabral, Norberto Luiz | - |
dc.contributor.author | Carolei, Antonio | - |
dc.contributor.author | Sacco, Simona | - |
dc.contributor.author | Chausson, Nicolas | - |
dc.contributor.author | Olindo, Stephane | - |
dc.contributor.author | Rothwell, Peter | - |
dc.contributor.author | Silva, Carolina | - |
dc.contributor.author | Correia, Manuel | - |
dc.contributor.author | Magalhães, Rui | - |
dc.contributor.author | Appelros, Peter | - |
dc.contributor.author | Kõrv, Janika | - |
dc.contributor.author | Vibo, Riina | - |
dc.contributor.author | Minelli, Cesar | - |
dc.contributor.author | Gall, Seana L | - |
dc.date | 2018-04-27 | - |
dc.date.accessioned | 2018-05-02T01:04:23Z | - |
dc.date.available | 2018-05-02T01:04:23Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Neurology 2018; 90(22): e1945-e1953 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/17546 | - |
dc.description.abstract | To examine factors contributing to the sex differences in functional outcomes and participation restriction after stroke. Individual participant data on long-term functional outcome or participation restriction (i.e., handicap) were obtained from 11 stroke incidence studies (1993-2014). Multivariable log-binomial regression was used to estimate the female:male relative risk (RR) of poor functional outcome (modified Rankin Scale score >2 or Barthel Index score <20) at 1 year (10 studies, n = 4,852) and 5 years (7 studies, n = 2,226). Multivariable linear regression was used to compare the mean difference (MD) in participation restriction by use of the London Handicap Scale (range 0-100 with lower scores indicating poorer outcome) for women compared to men at 5 years (2 studies, n = 617). For each outcome, study-specific estimates adjusted for confounding factors (e.g., sociodemographics, stroke-related factors) were combined with the use of random-effects meta-analysis. In unadjusted analyses, women experienced worse functional outcomes after stroke than men (1 year: pooled RRunadjusted 1.32, 95% confidence interval [CI] 1.18-1.48; 5 years: RRunadjusted 1.31, 95% CI 1.16-1.47). However, this difference was greatly attenuated after adjustment for age, prestroke dependency, and stroke severity (1 year: RRadjusted 1.08, 95% CI 0.97-1.20; 5 years: RRadjusted 1.05, 95% CI 0.94-1.18). Women also had greater participation restriction than men (pooled MDunadjusted -5.55, 95% CI -8.47 to -2.63), but this difference was again attenuated after adjustment for the aforementioned factors (MDadjusted -2.48, 95% CI -4.99 to 0.03). Worse outcomes after stroke among women were explained mostly by age, stroke severity, and prestroke dependency, suggesting these potential targets to improve the outcomes after stroke in women. | - |
dc.language.iso | eng | - |
dc.title | Factors contributing to sex differences in functional outcomes and participation after stroke. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Neurology | - |
dc.identifier.affiliation | Menzies Institute for Medical Research Tasmania, University of Tasmania, Hobart, Australia | - |
dc.identifier.affiliation | Department of Health Management and Health Economics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam | - |
dc.identifier.affiliation | Department of Epidemiology and Biostatistics, Michigan State University, East Lansing | - |
dc.identifier.affiliation | Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton | - |
dc.identifier.affiliation | The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia | - |
dc.identifier.affiliation | University of Melbourne, Victoria, Australia | - |
dc.identifier.affiliation | Faculty of Health and Medicine, University of Newcastle | - |
dc.identifier.affiliation | George Institute for Global Health, University of Sydney, New South Wales, Australia | - |
dc.identifier.affiliation | Hellenic Cardiovascular Research Society, Athens, Greece | - |
dc.identifier.affiliation | National Institute for Stroke and Applied Neurosciences, School of Public Health and Psychosocial Studies, Auckland University of Technology | - |
dc.identifier.affiliation | School of Psychology, University of Auckland, New Zealand | - |
dc.identifier.affiliation | University of Burgundy, University Hospital of Dijon, France | - |
dc.identifier.affiliation | Clinica Neurológica de Joinville, Joinville Stroke Registry, University of Joinville Region, Brazil | - |
dc.identifier.affiliation | Department of Biotechnological and Applied Clinical Sciences, Neurological Institute, University of L'Aquila, Italy | - |
dc.identifier.affiliation | Stroke Unit, Centre Hospitalier Sud Francilien, Corbeil-Essonnes | - |
dc.identifier.affiliation | Stroke Unit, University Hospital of Bordeaux, France | - |
dc.identifier.affiliation | Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK | - |
dc.identifier.affiliation | UNIFAI, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Portugal | - |
dc.identifier.affiliation | Department of Neurology, Faculty of Medicine and Health, Örebro University, Sweden | - |
dc.identifier.affiliation | Department of Neurology and Neurosurgery, University of Tartu, Estonia | - |
dc.identifier.affiliation | Hospital Carlos Fernando Malzoni and Neurologic Center of Research and Rehabilitation, Matão, SP, Brazil | - |
dc.identifier.doi | 10.1212/WNL.0000000000005602 | - |
dc.identifier.orcid | 0000-0001-8162-682X | - |
dc.identifier.pubmedid | 29703773 | - |
dc.type.austin | Journal Article | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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