Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17523
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dc.contributor.authorClay, T D-
dc.contributor.authorRussell, P A-
dc.contributor.authorDo, H-
dc.contributor.authorSundararajan, V-
dc.contributor.authorConron, M-
dc.contributor.authorWright, G M-
dc.contributor.authorDobrovic, Alexander-
dc.contributor.authorMoore, M M-
dc.contributor.authorMcLachlan, S A-
dc.date2015-12-12-
dc.date.accessioned2018-04-24T06:54:31Z-
dc.date.available2018-04-24T06:54:31Z-
dc.date.issued2016-01-
dc.identifier.citationPathology 2016; 48(1): 17-24-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17523-
dc.description.abstractWe sought to investigate the frequency of mutations in epidermal growth factor receptor (EGFR) and Kirsten-RAS (KRAS) by each pathological subtype for patients with resected pulmonary adenocarcinoma as defined by the IASLC/ATS/ERS classification. Histological examination determined the predominant subtype according to the IASLC/ATS/ERS classification. EGFR and KRAS mutations were determined by high-resolution melting and Sanger sequencing. Clinical data were collected from medical records and clinicians. The 178 consecutive patients consisted of 48% males, median age 68 years (range 20-87) and smoking history 78%. The tumour stage was I in 62%, II in 18% and III in 20%. The mutation rates were: EGFR 30%; KRAS 28%. The rate of EGFR mutations in the acinar predominant reference group (n=76), was 37%. The solid predominant subtype showed significantly fewer EGFR mutations [3/33 (9%), odds ratio 0.17 (0.05-0.61), p=0.007]. No differences in mutation rate were observed in other subtypes. No association was found between KRAS mutations and predominant histological subtype. Advanced stage and solid predominant subtype were negative prognostic factors. EGFR mutations can be present in adenocarcinoma of any predominant subtype, however rarely in solid predominant tumours. No association was found between KRAS mutation and the predominant histological subtype.-
dc.language.isoeng-
dc.subjectEGFR-
dc.subjectIASLC/ATS/ERS classification-
dc.subjectKRAS-
dc.subjectLung adenocarcinoma-
dc.titleAssociations between the IASLC/ATS/ERS lung adenocarcinoma classification and EGFR and KRAS mutations.-
dc.typeJournal Article-
dc.identifier.journaltitlePathology-
dc.identifier.affiliationSt Vincent's Hospital, Melbourne, Australia-
dc.identifier.affiliationUniversity of Melbourne, Australia-
dc.identifier.affiliationTranslational Genomics and Epigenetics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia-
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Australia-
dc.identifier.affiliationPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia-
dc.identifier.doi10.1016/j.pathol.2015.11.002-
dc.identifier.pubmedid27020204-
dc.type.austinComparative Study-
dc.type.austinJournal Article-
local.name.researcherDobrovic, Alexander
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptSurgery (University of Melbourne)-
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