Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17400
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dc.contributor.authorWilson, Danielle L-
dc.contributor.authorWalker, Susan P-
dc.contributor.authorFung, Alison M-
dc.contributor.authorPell, Gabrielle-
dc.contributor.authorO'Donoghue, Fergal J-
dc.contributor.authorBarnes, Maree-
dc.contributor.authorHoward, Mark E-
dc.date2018-01-25-
dc.date.accessioned2018-04-11T01:10:42Z-
dc.date.available2018-04-11T01:10:42Z-
dc.date.issued2018-
dc.identifier.citationJournal of Sleep Research 2018; 27(5): e12656en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17400-
dc.description.abstractSleep-disordered breathing is more common in hypertensive disorders during pregnancy; however, most studies have not adequately accounted for the potential confounding impact of obesity. This study evaluated the frequency of sleep-disordered breathing in women with gestational hypertension and pre-eclampsia compared with body mass index- and gestation-matched normotensive pregnant women. Women diagnosed with gestational hypertension or pre-eclampsia underwent polysomnography shortly after diagnosis. Normotensive controls body mass index-matched within ±4 kg m-2underwent polysomnography within ±4 weeks of gestational age of their matched case. The mean body mass index and gestational age at polysomnography were successfully matched for 40 women with gestational hypertension/pre-eclampsia and 40 controls. The frequency of sleep-disordered breathing in the cases was 52.5% compared with 37.5% in the control group (P = 0.18), and the respiratory disturbance index overall did not differ (P = 0.20). However, more severe sleep-disordered breathing was more than twice as common in women with gestational hypertension or pre-eclampsia (35% versus 15%, P = 0.039). While more than half of women with a hypertensive disorder of pregnancy meet the clinical criteria for sleep-disordered breathing, it is also very common in normotensive women of similar body mass index. This underscores the importance of adjusting for obesity when exploring the relationship between sleep-disordered breathing and hypertension in pregnancy. More severe degrees of sleep-disordered breathing are significantly associated with gestational hypertension and pre-eclampsia, and sleep-disordered breathing may plausibly play a role in the pathophysiology of pregnancy hypertension in these women. This suggests that more severe sleep-disordered breathing is a potential therapeutic target for reducing the prevalence or severity of hypertensive disorders in pregnancy.en_US
dc.language.isoeng-
dc.subjectobeseen_US
dc.subjectobstructive sleep apneaen_US
dc.subjectpregnanten_US
dc.subjectsleep studyen_US
dc.titleSleep-disordered breathing in hypertensive disorders of pregnancy: a BMI-matched study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Sleep Researchen_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationMercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.doi10.1111/jsr.12656en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-6754-7359en_US
dc.identifier.pubmedid29368415-
dc.type.austinJournal Article-
local.name.researcherBarnes, Maree
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptInstitute for Breathing and Sleep-
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