Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBorschmann, Karen-
dc.contributor.authorIuliano, Sandra-
dc.contributor.authorGhasem-Zadeh, Ali-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorPang, Marco Y C-
dc.contributor.authorBernhardt, Julie-
dc.identifier.citationArchives of Osteoporosis 2018; 13(1): 5en_US
dc.description.abstractBone fragility contributes to increased fracture risk, but little is known about the emergence of post-stroke bone loss. We investigated skeletal changes and relationships with physical activity, stroke severity, motor control and lean mass within 6 months of stroke. This is a prospective observational study. Participants were non-diabetic but unable to walk within 2 weeks of first stroke. Distal tibial volumetric bone mineral density (vBMD, primary outcome), bone geometry and microstructure (high-resolution peripheral quantitative computed tomography) were assessed at baseline and 6 months, as were secondary outcomes total body bone mineral content and lean mass (dual energy X-ray absorptiometry), bone metabolism (serum osteocalcin, N-terminal propeptide of type 1 procollagen (P1NP), C-terminal telopeptide of type 1 collagen (CTX)), physical activity (PAL2 accelerometer) and motor control (Chedoke McMaster) which were also measured at 1 and 3 months. Thirty-seven participants (69.7 years (SD 11.6), 37.8% females, NIHSS 12.6 (SD 4.7)) were included. The magnitude of difference in vBMD between paretic and non-paretic legs increased within 6 months, with a greater reduction observed in paretic legs (mean difference = 1.5% (95% CI 0.5, 2.6), p = 0.007). At 6 months, better motor control was associated with less bone loss since stroke (r = 0.46, p = 0.02). A trend towards less bone loss was observed in people who regained independent walking compared to those who did not (p = 0.053). Higher baseline daily count of standing up was associated with less change in bone turnover over 6 months: osteocalcin (r = -0.51, p = 0.01), P1NP (r = -0.47, p = 0.01), CTX (r = -0.53, p = 0.01). Better motor control and walking recovery were associated with reduced bone loss. Interventions targeting these impairments from early post-stroke are warranted. URL: . Unique identifier: ACTRN12612000123842.en_US
dc.subjectBone lossen_US
dc.subjectBone mineral densityen_US
dc.subjectPhysical activityen_US
dc.titleUpright activity and higher motor function may preserve bone mineral density within 6 months of stroke: a longitudinal study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleArchives of Osteoporosisen_US
dc.identifier.affiliationSchool of Health Science, La Trobe University, Bundoora, Australiaen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationDepartment of Rehabilitation Sciences, Hong Kong Polytechnic University, Hung Hom, Hong Kongen_US
dc.type.austinJournal Article-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Florey Institute of Neuroscience and Mental Health- (University of Melbourne)- (University of Melbourne)- Florey Institute of Neuroscience and Mental Health-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on Jun 1, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.