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dc.contributor.authorCabrini, Luca-
dc.contributor.authorLandoni, Giovanni-
dc.contributor.authorBaiardo Radaelli, Martina-
dc.contributor.authorSaleh, Omar-
dc.contributor.authorVotta, Carmine D-
dc.contributor.authorFominskiy, Evgeny-
dc.contributor.authorPutzu, Alessandro-
dc.contributor.authorSnak de Souza, Cézar Daniel-
dc.contributor.authorAntonelli, Massimo-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorPelosi, Paolo-
dc.contributor.authorZangrillo, Alberto-
dc.identifier.citationCritical Care 2018; 22(1): 6-
dc.description.abstractWe performed a systematic review of randomized controlled studies evaluating any drug, technique or device aimed at improving the success rate or safety of tracheal intubation in the critically ill. We searched PubMed, BioMed Central, Embase and the Cochrane Central Register of Clinical Trials and references of retrieved articles. Finally, pertinent reviews were also scanned to detect further studies until May 2017. The following inclusion criteria were considered: tracheal intubation in adult critically ill patients; randomized controlled trial; study performed in Intensive Care Unit, Emergency Department or ordinary ward; and work published in the last 20 years. Exclusion criteria were pre-hospital or operating theatre settings and simulation-based studies. Two investigators selected studies for the final analysis. Extracted data included first author, publication year, characteristics of patients and clinical settings, intervention details, comparators and relevant outcomes. The risk of bias was assessed with the Cochrane Collaboration's Risk of Bias tool. We identified 22 trials on use of a pre-procedure check-list (1 study), pre-oxygenation or apneic oxygenation (6 studies), sedatives (3 studies), neuromuscular blocking agents (1 study), patient positioning (1 study), video laryngoscopy (9 studies), and post-intubation lung recruitment (1 study). Pre-oxygenation with non-invasive ventilation (NIV) and/or high-flow nasal cannula (HFNC) showed a possible beneficial role. Post-intubation recruitment improved oxygenation, while ramped position increased the number of intubation attempts and thiopental had negative hemodynamic effects. No effect was found for use of a checklist, apneic oxygenation (on oxygenation and hemodynamics), videolaryngoscopy (on number and length of intubation attempts), sedatives and neuromuscular blockers (on hemodynamics). Finally, videolaryngoscopy was associated with severe adverse effects in multiple trials. The limited available evidence supports a beneficial role of pre-oxygenation with NIV and HFNC before intubation of critically ill patients. Recruitment maneuvers may increase post-intubation oxygenation. Ramped position increased the number of intubation attempts; thiopental had negative hemodynamic effects and videolaryngoscopy might favor adverse events.-
dc.subjectCritically ill-
dc.subjectEmergency department-
dc.subjectHigh flow nasal cannula-
dc.subjectIntensive care unit-
dc.subjectTracheal intubation-
dc.titleTracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials.-
dc.typeJournal Article-
dc.identifier.journaltitleCritical Care-
dc.identifier.affiliationDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy-
dc.identifier.affiliationDepartment of Cardiovascular Anesthesia and Intensive Care, Cardiocentro Ticino, Lugano, Switzerland-
dc.identifier.affiliationDepartment of Surgery. Discipline of Anesthesiology, Critical Care and Pain Medicine, Federal University of São Paulo, São Paulo, Brazil-
dc.identifier.affiliationDepartment of Intensive Care Medicine and Anaesthesiology, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy-
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Surgical Sciences and Integrated Diagnostics, San Martino Policlinico Hospital, IRCCS for Oncology, University of Genoa, Largo Rosanna Benzi 8, 16131, Genoa, Italy.-
dc.type.austinJournal Article-, Rinaldo
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone- Care- Analytics Research and Evaluation (DARE) Centre-
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