Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16898
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dc.contributor.authorYerramilli, Arvind-
dc.contributor.authorTay, Ee Laine-
dc.contributor.authorStewardson, Andrew J-
dc.contributor.authorKelley, Peter G-
dc.contributor.authorBishop, Emma-
dc.contributor.authorJenkin, Grant A-
dc.contributor.authorStarr, Mike-
dc.contributor.authorTrevillyan, Janine-
dc.contributor.authorHughes, Andrew-
dc.contributor.authorFriedman, N Deborah-
dc.contributor.authorO’Brien, Daniel P-
dc.contributor.authorJohnson, Paul D R-
dc.date2017-08-18-
dc.date.accessioned2017-10-11T04:40:02Z-
dc.date.available2017-10-11T04:40:02Z-
dc.date.issued2017-08-
dc.identifier.citationPLoS Neglected Tropical Diseases 2017; 11(8): e0005800en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16898-
dc.description.abstractBACKGROUND: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. METHODS: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection. FINDINGS: We examined 579 patients with 649 lesions; 32 (5.5%) patients had multiple lesions. Lesions were predominantly located on lower (70.0%) and upper (27.1%) limbs, and showed a non-random distribution with strong predilection for the ankles, elbows and calves. When stratified by gender, upper limb lesions were more common (OR 1·97, 95% CI 1·38-2·82, p<0·001) while lower limb lesions were less common in men than in women (OR 0·48, 95% CI 0·34-0·68, p<0·001). Patients aged ≥ 65 years (OR 3·13, 95% CI 1·52-6·43, p = 0·001) and those with a lesion on the ankle (OR 2·49, 95% CI 1·14-5·43, p = 0·02) were more likely to have multiple lesions. Most infections (71.3%) were likely acquired in the warmer 6 months of the year. INTERPRETATION: Comparison with published work in Cameroon, Africa, showed similar lesion distribution and suggests the mode of M. ulcerans transmission may be the same across the globe. Our findings also aid clinical diagnosis and provide quantitative background information for further research investigating disease transmission.en_US
dc.titleThe location of Australian Buruli ulcer lesions-Implications for unravelling disease transmissionen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitlePLoS Neglected Tropical Diseasesen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationDepartment of Medicine and Infectious Diseases, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationHealth Protection Branch, Department of Health & Human Services, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Peninsula Health, Frankston, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Monash Health, Clayton, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of General Medicine, The Royal Children's Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Alfred Health, Prahran, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Barwon Health, Geelong, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28821017en_US
dc.identifier.doi10.1371/journal.pntd.0005800en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherJohnson, Paul D R
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptInfectious Diseases-
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