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dc.contributor.authorGranger, Catherine L-
dc.contributor.authorParry, Selina M-
dc.contributor.authorEdbrooke, Lara-
dc.contributor.authorDenehy, Linda-
dc.identifier.citationPhysiotherapy 2016; 102(3): 256-263en_US
dc.description.abstractObjectives To investigate in non-surgically and surgically treated non-small cell lung cancer (NSCLC): (1) changes in physical activity, function, health-related quality of life (HRQoL) and symptoms after diagnosis; and (2) the association between physical activity and outcomes. Design Prospective observational study. Setting Three acute tertiary hospitals. Participants Sixty-nine individuals (43 male, median [IQR] age 68 [61 to 74] years) with stage I–IV NSCLC. Main outcome measures The primary outcome (Physical Activity Scale for the Elderly) and secondary outcome (six-minute walk test and questionnaires assessing HRQoL, function, symptoms, mood) were measured at diagnosis (pre-treatment), and eight to ten weeks post-diagnosis (post-operative and/or during chemotherapy/radiotherapy). Results Individuals treated surgically (n = 27) experienced a deterioration in physical activity levels (baseline median [IQR] = 74 [51 to 135]; follow-up median [IQR] = 29 [24 to 73]; median difference = 45, effect size = 0.3). At follow-up physical activity was inversely related to depression, pain and appetite loss (rho > 0.5, p < 0.05). In contrast non-surgical individuals (n = 42) did not experience a change in physical activity, however did experience deterioration in function, functional capacity, global HRQoL, fatigue and dyspnoea. Physical activity levels were low in this group and at follow-up the strongest relationships with physical activity levels were global HRQoL, function, fatigue and mood (inverse, rho > 0.5, p < 0.05). Conclusions Surgically treated individuals experienced a reduction in physical activity levels after diagnosis, which was not seen in the non-surgical group. Lower physical activity levels were associated with poorer outcomes, particularly in non-surgically treated individuals. Further research is required to establish the optimal intervention to improve physical activity levels in these cohorts.en_US
dc.subjectLung neoplasmsen_US
dc.subjectNon-small cell lung canceren_US
dc.subjectPhysical activityen_US
dc.subjectHealth-related quality of lifeen_US
dc.titleDeterioration in physical activity and function differs according to treatment type in non-small cell lung cancer - future directions for physiotherapy managementen_US
dc.typeJournal Articleen_US
dc.identifier.affiliationInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Physiotherapy, The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Physiotherapy, Royal Melbourne Hospital, Parkville, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US, Catherine L
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype for Breathing and Sleep-
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