Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16768
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dc.contributor.authorO'Kane, D-
dc.contributor.authorGibson, L-
dc.contributor.authordu Plessis, J-
dc.contributor.authorDavidson, A-
dc.contributor.authorBolton, Damien M-
dc.contributor.authorLawrentschuk, Nathan-
dc.date2017-07-27-
dc.date.accessioned2017-08-03T06:04:44Z-
dc.date.available2017-08-03T06:04:44Z-
dc.date.issued2017-11-
dc.identifier.citationInternational Journal of Impotence Research 2017; 29(6): 225-228en_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16768-
dc.description.abstractED affects a significant proportion of males worldwide. With an ever-aging population the prevalence of ED is predicted to double in the next decade. Oral PDE-5 inhibitors are the first-line treatment for ED and have revolutionised its management. These agents are however ineffective in some men. Intracavernosal injection (ICI) of vasoactive agents is an effective second-line therapy for ED. Despite proven efficacy, needle phobia and anxiety with self-needling limit the use of intracavernosal (IC) therapies. Needle-free injection (NFI) devices allow delivery of parenteral therapies through the skin, without a needle. Although these devices have been available for decades, early studies investigating their use for ICI showed inferiority compared to standard needle-tip syringe delivery. Advances in engineering of these systems have lead to functional improvements of many aspects of fluid delivery. Our research demonstrates that modern NFI devices are better equipped to deliver ICI, and, in the cadaver models examined, achieved successful IC delivery. These findings support the potential feasibility of NFI devices to deliver ICI, and may broaden the utility of these devices to patients who refuse or discontinue IC therapy because of needle phobia or other issues with standard needle-tip syringes.en_US
dc.titleDelivery of intracavernosal therapies using needle-free injection devicesen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleInternational Journal of Impotence Researchen_US
dc.identifier.affiliationDepartment of Urology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationHealthscope Pathology, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28747647en_US
dc.identifier.doi10.1038/ijir.2017.27en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-8553-5618en_US
dc.identifier.orcid0000-0002-5145-6783en_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptUrology-
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