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dc.contributor.authorRobertson, Joanne S-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorVillemagne, Victor L-
dc.identifier.citationQuarterly Journal of Nuclear Medicine and Molecular Imaging 2017; 61(4): 405-413en_US
dc.description.abstractFolded and misfolded tau is common to many neurodegenerative conditions, collectively termed 'tauopathies'. In recent years, many efforts have contributed toward development of tau imaging agents to allow measurement of tau deposits in vivo using Positron Emission Tomography (PET). The particularities of tau present some unique challenges for the development of tau imaging tracers. Most notably, these pertain to the predominantly intracellular nature of tau aggregations, the existence of six isoforms, multiple post-translational modification, and that tau is usually surrounded by larger concentrations of A plaques. Nevertheless, significant progress has been made towards overcoming these issues and a number of tracers are now undergoing human trials. Once validated, tau imaging with PET will be a useful tool for the differential diagnosis and disease staging, as well as therapeutic trials of AD and non-AD tauopathies.en_US
dc.titleTau imaging with PET: an overview of challenges, current progress, and future applicationsen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleQuarterly Journal of Nuclear Medicine and Molecular Imagingen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Molecular Imaging and Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Imaging and Therapy- Imaging and Therapy-
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