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DC Field | Value | Language |
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dc.contributor.author | Bagshaw, Sean M | - |
dc.contributor.author | Gibney, RT Noel | - |
dc.contributor.author | Kruger, Peter | - |
dc.contributor.author | Hassan, Imran | - |
dc.contributor.author | McAlister, Finlay A | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.date | 2017-07-12 | - |
dc.date.accessioned | 2017-07-27T07:25:59Z | - |
dc.date.available | 2017-07-27T07:25:59Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | Journal of Critical Care 2017; 42: 138-146 | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/16747 | - |
dc.description.abstract | PURPOSE: Furosemide is commonly prescribed in acute kidney injury (AKI). Prior studies have found conflicting findings on whether furosemide modifies the course and outcome of AKI. METHODS: Pilot multi-center randomized blinded placebo-controlled trial in adult patients with AKI admitted to three intensive care units. Participants were randomly allocated to furosemide bolus and infusion or 0.9% saline placebo. Primary endpoint was worsening AKI, defined by the RIFLE criteria. Secondary endpoints were kidney recovery, renal replacement therapy (RRT) and adverse events. RESULTS: The trial was terminated after enrollment of 73 participants (37 to furosemide and 36 to placebo). Mean (SD) age was 61.7 (14.3), 79.5% were medical admissions, mean (SD) APACHE II score was 26.6 (7.8), 90.4% received mechanical ventilation and 61.6% received vasoactives. Groups were similar at baseline. No differences were found in the proportion with worsening AKI (43.2% vs. 37.1%, p=0.6), kidney recovery (29.7% vs. 42.9%, p=0.3), or RRT (27.0% s. 28.6%, p=0.8). Adverse events, mostly electrolyte abnormalities, were more common in furosemide-treated patients (p<0.001). Protocol deviations were common, due often to supplementary furosemide. CONCLUSIONS: In this pilot trial, furosemide did not reduce the rate of worsening AKI, improve recovery or reduce RRT; however, was associated with greater electrolyte abnormalities. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00978354 registered September 9, 2014. | en_US |
dc.subject | Acute kidney injury | en_US |
dc.subject | Furosemide | en_US |
dc.subject | Mortality | en_US |
dc.subject | Placebo | en_US |
dc.subject | Randomized | en_US |
dc.subject | Recovery | en_US |
dc.subject | Renal replacement therapy | en_US |
dc.subject | Urine output | en_US |
dc.title | The effect of low-dose furosemide in critically ill patients with early acute kidney injury: a pilot randomized blinded controlled trial (the SPARK study) | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Journal of Critical Care | en_US |
dc.identifier.affiliation | Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Clinical Science Building, Edmonton, Alberta, Canada | en_US |
dc.identifier.affiliation | Department of Intensive Care Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia | en_US |
dc.identifier.affiliation | School of Medicine, University of Queensland, Queensland, Australia | en_US |
dc.identifier.affiliation | Epidemiology Coordinating and Research Centre (EPICORE), Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada | en_US |
dc.identifier.affiliation | Division of General Internal Medicine, Faculty of Medicine and Dentistry, University of Alberta, Clinical Science Building, Edmonton, Alberta, Canada | en_US |
dc.identifier.affiliation | Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia | en_US |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/28732314 | en_US |
dc.identifier.doi | 10.1016/j.jcrc.2017.07.030 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0002-1650-8939 | - |
dc.type.austin | Journal Article | en_US |
local.name.researcher | Bellomo, Rinaldo | |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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