Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/16728
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DC Field | Value | Language |
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dc.contributor.author | Kinnunen, Kirsi M | - |
dc.contributor.author | Cash, David M | - |
dc.contributor.author | Poole, Teresa | - |
dc.contributor.author | Frost, Chris | - |
dc.contributor.author | Benzinger, Tammie LS | - |
dc.contributor.author | Ahsan, R Laila | - |
dc.contributor.author | Leung, Kelvin K | - |
dc.contributor.author | Cardoso, M Jorge | - |
dc.contributor.author | Modat, Marc | - |
dc.contributor.author | Malone, Ian B | - |
dc.contributor.author | Morris, John C | - |
dc.contributor.author | Bateman, Randall J | - |
dc.contributor.author | Marcus, Daniel S | - |
dc.contributor.author | Goate, Alison | - |
dc.contributor.author | Salloway, Stephen | - |
dc.contributor.author | Correia, Stephen | - |
dc.contributor.author | Sperling, Reisa A | - |
dc.contributor.author | Chhatwal, Jasmeer P | - |
dc.contributor.author | Mayeux, Richard | - |
dc.contributor.author | Brickman, Adam M | - |
dc.contributor.author | Martins, Ralph N | - |
dc.contributor.author | Farlow, Martin R | - |
dc.contributor.author | Ghetti, Bernardino | - |
dc.contributor.author | Saykin, Andrew J | - |
dc.contributor.author | Jack, Clifford R Jr | - |
dc.contributor.author | Schofield, Peter R | - |
dc.contributor.author | McDade, Eric | - |
dc.contributor.author | Weiner, Michael W | - |
dc.contributor.author | Ringman, John M | - |
dc.contributor.author | Thompson, Paul M | - |
dc.contributor.author | Masters, Colin L | - |
dc.contributor.author | Rowe, Christopher C | - |
dc.contributor.author | Rossor, Martin N | - |
dc.contributor.author | Ourselin, Sebastien | - |
dc.contributor.author | Fox, Nick C | - |
dc.contributor.author | Dominantly Inherited Alzheimer Network (DIAN) | - |
dc.date | 201-07-22 | - |
dc.date.accessioned | 2017-07-26T01:12:31Z | - |
dc.date.available | 2017-07-26T01:12:31Z | - |
dc.date.issued | 2017-07-22 | - |
dc.identifier.citation | Alzheimer's & Dementia 2017; online first: 22 July | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/16728 | - |
dc.description.abstract | INTRODUCTION: Identifying at what point atrophy rates first change in Alzheimer's disease is important for informing design of presymptomatic trials. METHODS: Serial T1-weighed magnetic resonance imaging scans of 94 participants (28 noncarriers, 66 carriers) from the Dominantly Inherited Alzheimer Network were used to measure brain, ventricular, and hippocampal atrophy rates. For each structure, nonlinear mixed-effects models estimated the change-points when atrophy rates deviate from normal and the rates of change before and after this point. RESULTS: Atrophy increased after the change-point, which occurred 1-1.5 years (assuming a single step change in atrophy rate) or 3-8 years (assuming gradual acceleration of atrophy) before expected symptom onset. At expected symptom onset, estimated atrophy rates were at least 3.6 times than those before the change-point. DISCUSSION: Atrophy rates are pathologically increased up to seven years before "expected onset". During this period, atrophy rates may be useful for inclusion and tracking of disease progression. | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Atrophy | en_US |
dc.subject | Autosomal dominant | en_US |
dc.subject | Boundary Shift Integral | en_US |
dc.subject | Change-point | en_US |
dc.subject | Dementia | en_US |
dc.subject | Longitudinal | en_US |
dc.subject | MRI | en_US |
dc.subject | Neuroimaging | en_US |
dc.subject | Nonlinear modeling | en_US |
dc.title | Presymptomatic atrophy in autosomal dominant Alzheimer's disease: a serial MRI study | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Alzheimer's & Dementia | en_US |
dc.identifier.affiliation | Dementia Research Centre, UCL Institute of Neurology, London, UK | en_US |
dc.identifier.affiliation | Translational Imaging Group, UCL Centre for Medical Image Computing, London, UK | en_US |
dc.identifier.affiliation | London School of Hygiene & Tropical Medicine, London, UK | en_US |
dc.identifier.affiliation | Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA | en_US |
dc.identifier.affiliation | Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA | en_US |
dc.identifier.affiliation | Department of Neurological Surgery & Psychiatry, Washington University School of Medicine, St. Louis, MO, USA | en_US |
dc.identifier.affiliation | Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA | en_US |
dc.identifier.affiliation | Brown University-Butler Hospital, Providence, RI, USA | en_US |
dc.identifier.affiliation | Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA | en_US |
dc.identifier.affiliation | Department of Neurology, Columbia University Medical Center, New York, NY, USA | en_US |
dc.identifier.affiliation | School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia | en_US |
dc.identifier.affiliation | Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA | en_US |
dc.identifier.affiliation | Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA | en_US |
dc.identifier.affiliation | Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA | en_US |
dc.identifier.affiliation | Department of Radiology, Mayo Clinic, Rochester, MN, USA | en_US |
dc.identifier.affiliation | Neuroscience Research Australia, Randwick, NSW, Australia | en_US |
dc.identifier.affiliation | School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia | en_US |
dc.identifier.affiliation | Department of Radiology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA | en_US |
dc.identifier.affiliation | Department of Neurology, Keck USC School of Medicine, Los Angeles, CA, USA | en_US |
dc.identifier.affiliation | Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA | en_US |
dc.identifier.affiliation | The Florey Institute, The University of Melbourne, Heidelberg, Victoria, Australia | en_US |
dc.identifier.affiliation | Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia | en_US |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia | en_US |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/28738187 | en_US |
dc.identifier.doi | 10.1016/j.jalz.2017.06.2268 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0003-3910-2453 | en_US |
dc.type.austin | Journal Article | en_US |
local.name.researcher | Masters, Colin L | |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
Appears in Collections: | Journal articles |
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